78-27-3 Usage
Description
1-Ethynyl-1-cyclohexanol, also known as ECHO, is a colorless liquid with unique chemical properties. It is a versatile organic compound that can be used in various applications across different industries.
Uses
Used in Chemical Synthesis:
1-Ethynyl-1-cyclohexanol is used as an intermediate for the synthesis of various organic compounds. It can undergo acetylation in the presence of a catalytic amount of ruthenium chloride at room temperature, allowing for the creation of new chemical entities.
Used in Stabilization of Chlorinated Organic Compounds:
1-Ethynyl-1-cyclohexanol is used as a stabilizer for chlorinated organic compounds, helping to prevent their degradation and ensuring their stability during storage and use.
Used in Corrosion Inhibition:
1-Ethynyl-1-cyclohexanol serves as a corrosion inhibitor for mineral acids, protecting metal surfaces from corrosion and extending their lifespan.
Used in Pharmaceutical Industry:
1-Ethynyl-1-cyclohexanol is used as a sedative in medicine, providing calming effects and helping to alleviate anxiety and stress.
Used in Organotellurium(IV) Compounds Synthesis:
1-Ethynyl-1-cyclohexanol can be used to synthesize novel organotellurium(IV) compounds with potent inhibitory activity towards Cathepsin B, a protease enzyme implicated in various diseases.
Used in Polymer Synthesis:
The polymerization of ECHO by transition metal catalysts leads to the formation of poly(ECHO), which can be used in various applications, such as in the development of new materials with unique properties.
Used in Vinyl Derivative Synthesis:
1-Ethynyl-1-cyclohexanol can react with transition metal hydride complexes to form vinyl derivatives by inserting into the M-H bonds, providing a route to synthesize new vinyl compounds for various applications.
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 3, p. 416, 1955Synthetic Communications, 18, p. 131, 1988 DOI: 10.1080/00397918808077336
Flammability and Explosibility
Nonflammable
Check Digit Verification of cas no
The CAS Registry Mumber 78-27-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 78-27:
(4*7)+(3*8)+(2*2)+(1*7)=63
63 % 10 = 3
So 78-27-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H12O/c1-2-8(9)6-4-3-5-7-8/h1,9H,3-7H2
78-27-3Relevant articles and documents
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Merienne et al.
, p. 281,282 (1973)
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Fluorocyclization of Allyl Alcohols and Amines to Access 3-Functionalized Oxetanes and Azetidines
Cao, Shanshan,Li, Linxuan,Liu, Zhaohong,Ning, Yongquan,Wu, Yong,Zanoni, Giuseppe,Zhang, Qi,Zhang, Xinyu
supporting information, p. 3674 - 3679 (2021/05/31)
An efficient method to prepare 3-functionalized oxetanes and azetidines has been realized by fluorocyclization of readily available 2-azidoallyl/2-alkoxyallyl alcohols and amines. Notably, this is the first example applying the fluorocyclization strategy to construct four-membered heterocycles. The pendant electron-donating group (-N3 or -OR) plays a crucial role in polarizing the C= C double bond and facilitating the cyclization process, as verified by DFT and experimental studies.
ETHERS AND ESTERS OF 1-SUBSTITUTED CYCLOALKANOLS FOR USE AS AROMA CHEMICALS
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Page/Page column 52, (2020/05/21)
The present invention relates to the use of an ether or an ester of a 1 -substituted cycloalkanol or of mixtures of two or more ethers or esters of 1 -substituted cycloalkanols or of a stereoisomer thereof or of a mixture of two or more stereoisomers thereof as aroma chemicals; to the use thereof for modifying the scent character of a fragranced composition; to an aroma chemical composition containing an ether or an ester of a 1 -substituted cycloalkanol or of mixtures of two or more ethers or esters of 1 -substituted cycloalkanols or of a stereoisomer thereof or of a mixture of two or more stereoisomers thereof; and to a method of preparing a fragranced composition or for modifying the scent character of a fragranced composition. The invention further relates to specific ethers or esters of 1 -substituted cycloalkanols.