78-96-6 Usage
Description
Amino-2-propanol, also known as 1-amino-2-propanol or 1-aminopropan-2-ol, is an organic compound with the chemical formula C3H9NO. It is a colorless liquid with a slight ammonia-like odor and a fishy smell when concentrated. Amino-2-propanol is less dense than water and soluble in water. It has a flash point of 165°F and is corrosive to metals and tissue. The vapors of this compound are heavier than air and produce toxic oxides of nitrogen during combustion.
Uses
Used in Machine Lubricating/Cutting Oil Formulations:
Amino-2-propanol is used as an additive in synthetic and semi-synthetic machine lubricating and cutting oil formulations. It is used along with isopropanolamine, diisopropanolamine, and triethanolamine, as well as nitrites. The Environmental Protection Agency (EPA) has established standards regarding the composition of cutting fluids, which include the use of Amino-2-propanol.
Used in Pharmaceutical Research:
Amino-2-propanol is utilized in the study of the effect of temperature and water content on its molecular structure and hydrogen bonding. This research has been conducted using Fourier transform near-infrared (FT-NIR) spectroscopy. Additionally, Amino-2-propanol is used in the synthesis of protein kinase CK2 inhibitors, which are employed in the treatment of neoplasia and other infective diseases.
Used in Chemical Synthesis:
Amino-2-propanol serves as a reactant in the preparation of various compounds. It can be used to synthesize 5-methyl-2-oxazolidinone through an oxidative carbonylation reaction using a Pd(OAc)2/I2 catalyst. Furthermore, it can be employed in the production of bio-based polyurethanes by reacting with epoxidized soybean oil through ring-opening and amidation reactions. Amino-2-propanol can also function as a solvent and a template for synthesizing layered aluminophosphate containing a racemic mixture of isopropanolamine.
Used in the Production of Plastics, Paints, and Cleaning Compounds:
Amino-2-propanol is utilized in the manufacturing of plastics, paints, and specialized cleaning compounds. Its properties make it a suitable component for these industries, contributing to the development of various products.
Occurrence:
Amino-2-propanol has been reportedly found in sherry, indicating its presence in the food and beverage industry as well.
Preparation
By employing Salmonella, mutatant cobD, and aminopropanol
Air & Water Reactions
Water soluble.
Reactivity Profile
Amino-2-propanol is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard
Vapor irritates eyes and nose. Liquid causes local injury to mouth, throat, digestive tract, skin, and eyes.
Safety Profile
Poison by intraperitoneal route.Moderately toxic by ingestion and skin contact. A skin andsevere eye irritant. Moderately flammable in presence ofheat, flame, sparks, powerful oxidizers. Ignites on contactwith cellulose nitrate of high surface area. C
Check Digit Verification of cas no
The CAS Registry Mumber 78-96-6 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 8 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 78-96:
(4*7)+(3*8)+(2*9)+(1*6)=76
76 % 10 = 6
So 78-96-6 is a valid CAS Registry Number.
InChI:InChI:1S/C3H9NO/c1-3(5)2-4/h3,5H,2,4H2,1H3
78-96-6Relevant articles and documents
ZEOLITE CATALYZED PROCESS FOR THE AMINATION OF PROPYLENE OXIDE
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Page/Page column 20-21, (2021/05/29)
The present invention relates to a process for the conversion of propylene oxide to 1-amino-2- propanol and/or di(2-hydroxypropyl)amine comprising (i) providing a catalyst comprising a zeolitic material comprising YO2 and optionally comprising X2O3 in its framework structure, wherein Y is a tetravalent element and X is a trivalent element, wherein the zeolitic material has a framework-type structure selected from the group consisting of MFI and/or MEL, including MEL/MFI intergrowths; (ii) providing a mixture in the liquid phase comprising propylene oxide and ammonia; (iii) contacting the catalyst provided in (i) with the mixture in the liquid phase provided in (ii) for converting propylene oxide to 1-amino-2-propanol and/or di(2-hydroxypropyl)amine.
Selective amination of 1,2-propanediol over Co/La3O4 catalyst prepared by liquid-phase reduction
Yue, Chuan-Jun,Di, Kai,Gu, Li-Ping,Zhang, Zhen-Wei,Ding, Lin-Lin
, (2019/08/20)
The catalytic coupling of alcohol and ammonia is an environmentally friendly process. Cobalt-based catalysts, modified by supports (including CeO2, Fe3O4, Nb2O5, La3O4 and Al2O3), and prepared by the liquid-phase reduction, were used for the amination of 1,2-propanediol. The screened nano-Co/La3O4 catalyst exhibited an excellent catalytic performance of 68% conversion and 89% selectivity toward 2-amino-1-propanol under optimal conditions. The characterizations of the catalyst was performed by XRD, XPS, BET, TEM, TG, and CO2-TPD, revealing a relatively large specific surface area, strongly alkaline sites and a Co-La-O transition phase, which were responsible for the selective catalysis of 1,2-propanediol. The efficient construction of cobalt-based catalysts on the basis of the active species is key to improving the efficiency of the reaction process.
Lewis acid mediated intramolecular C-O bond formation of alkanol-epoxide leading to substituted morpholine and 1,4-oxazepane derivatives: Total synthesis of (±)-Viloxazine
Ghosh, Priya,Deka, Manash J.,Saikia, Anil K.
, p. 690 - 698 (2016/01/15)
Substituted morpholines have been efficiently synthesised in good yields from nitrogen tethered alkanol-epoxide mediated by boron trifluoride etherate. The methodology has been used for the total synthesis of (±)-viloxazine.
