782-08-1

Basic information

• Product Name: 1,1'-(chloromethylene)bis[4-chlorobenzene]
• Synonyms: 1,1'-(chloromethylene)bis[4-chlorobenzene];1,1-bis(4-chlorophenyl)chloromethane;Bis(p-chlorophenyl)chloromethane;4,4'-(Chloromethylene)bis(chlorobenzene);Benzene,1,1'-(chloroMethylene)bis[4-chloro-;4,4'-Dichlorobenzhydrylchloride
• CAS NO: 782-08-1
• Molecular Formula: C₁₃H₉Cl₃
• Molecular Weight: 271.56956
• EINECS: 212-311-0
• Mol File: 782-08-1.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 214-216 °C(Press: 2.5 Torr)
• Appearance: /
• Density: 1.325±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1,1'-(chloromethylene)bis[4-chlorobenzene](CAS DataBase Reference)
• NIST Chemistry Reference: 1,1'-(chloromethylene)bis[4-chlorobenzene](782-08-1)
• EPA Substance Registry System: 1,1'-(chloromethylene)bis[4-chlorobenzene](782-08-1)

Safety Data

• Hazardous Substances Data: 782-08-1(Hazardous Substances Data)

Usage

General Description

1,1'-(chloromethylene)bis[4-chlorobenzene] is a chemical compound. It is a pale yellow solid with a molecular formula of C13H8Cl2 and a molecular weight of 231.11 g/mol. 1,1'-(chloromethylene)bis[4-chlorobenzene] is primarily used as a building block in the production of various organic compounds and has applications in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in the manufacturing of dyes, pigments, and polymers. However, it is important to handle this chemical with care as it is toxic to aquatic life and may cause skin irritation and respiratory problems in humans if not handled properly. Additionally, it is not considered to be readily biodegradable and can persist in the environment, posing potential long-term risks.

Upstream product

• 4732-69-8 Chloro-oxo-acetic acid 
• 90-97-1 4,4'-dichlorobenzophenone 
• 119-56-2 (4-chlorophenyl)phenylmethanol 
• 90-98-2 4,4'-Dichlorobenzophenone 
• 7647-01-0 hydrogenchloride 
• 71-43-2 benzene 
• 101-76-8 4,4'-dichlorodiphenylmethane 

Downstream Products

• 101784-44-5 1-(bis(4-chlorophenyl)methyl)-4-methylpiperazine 
• 635320-01-3 bis(4-chlorophenyl)methanethiol 
• 123124-51-6 N-(4,4'-dichlorobenzhydryl)piperidine 
• 103294-87-7 1-[bis(4-chlorophenyl)methyl]-1H-1,2,3-triazole 
• 123124-55-0 2-[bis(4-chlorophenyl)methyl]-2H-1,2,3-triazole 
• 102994-04-7 1--1H-1,2,4-triazole 
• 102994-05-8 4--4H-1,2,4-triazole 
• 90-97-1 4,4'-dichlorobenzophenone 
• 57070-99-2 4,4'-dichlorobenzhydryl ethyl ether 
• 117959-66-7 9-[Bis-(4-chloro-phenyl)-methyl]-9-phenyl-9H-fluorene 
• 103294-86-6 2--2H-tetrazole 
• 99905-01-8 4',4''-Dichloro-3alpha-(diphenylmethoxy)tropane hydrochloride 
• 102448-91-9 4',4''-Dichloro-3alpha-(diphenylmethoxy)tropane 
• 1332836-34-6 1-(bis(4-chlorophenyl)methyl)-3-decylimidazol-3-ium bromide 

Relevant articles and documents

Capture of benzhydryl chloride ion pairs by cobalt nitrate

A case is presented where a transition metal salt, Co(NO3)2, intervenes in the solvolysis of benzhydryl chloride, after the rate determining ionization step. This is in contrast to the behavior of other salts which intervene early and promote the ionization reaction. This novel behavior of Co(NO3)2 permits for the first time the detection of two ion pair intermediates in the solvolysis of an alkyl chloride which generates an open carbonium ion.

Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection

Recently, we reported that chlorcyclizine (CCZ, Rac-2), an over-the-counter antihistamine piperazine drug, possesses in vitro and in vivo activity against hepatitis C virus. Here, we describe structure-activity relationship (SAR) efforts that resulted in the optimization of novel chlorcyclizine derivatives as anti-HCV agents. Several compounds exhibited EC50 values below 10 nM against HCV infection, cytotoxicity selectivity indices above 2000, and showed improved in vivo pharmacokinetic properties. The optimized molecules can serve as lead preclinical candidates for the treatment of hepatitis C virus infection and as probes to study hepatitis C virus pathogenesis and host-virus interaction.

Phosphine functionalized polyphosphazenes: soluble and re-usable polymeric reagents for highly efficient halogenations under Appel conditions

In this paper we present the preparation and application of a novel soluble phosphine functionalized polyphosphazene (poly[3-(diphenylphosphino)propylamino]phosphazene) and investigate its application as a polymeric reagent. Upon chlorination of the pendant phosphine groups, the polymer was found to facilitate the rapid and efficient transformation of alcohols to the corresponding chlorides and bromides under Appel-type conditions. Reaction times followed by 31P NMR spectroscopy are shown to be rapid (several minutes) and the yields for the transformation of alcohols to the corresponding halides are in the range 80–99?%. The facile recovery of the oxidized polymeric agent by precipitation is also described, offering a significant advantage over notoriously difficult to remove small molecule phosphine oxide by-products. Furthermore the regeneration of the reactive phosphine chloride pendant groups is demonstrated, which could be efficiently re-used in a further chlorination reaction. Graphical abstract: [Figure not available: see fulltext.]