78504-35-5

Basic information

• Product Name: diethyl (2-methylphenyl)phosphoramidate
• CAS NO: 78504-35-5
• Molecular Formula: C₁₁H₁₈NO₃P
• Molecular Weight: 243.2393
• Mol File: 78504-35-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 303.3°C at 760 mmHg
• Flash Point: 137.2°C
• Density: 1.149g/cm³
• Vapor Pressure: 0.000937mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: diethyl (2-methylphenyl)phosphoramidate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (2-methylphenyl)phosphoramidate(78504-35-5)
• EPA Substance Registry System: diethyl (2-methylphenyl)phosphoramidate(78504-35-5)

Safety Data

• Hazardous Substances Data: 78504-35-5(Hazardous Substances Data)

Upstream product

• 89792-75-6 o-tolyl-amidophosphoryl chloride 
• 4828-91-5 triethyl N-(o-tolyl)phosphorimidate 
• 636-21-5 o-toluidine hydrochloride 
• 95-53-4 o-toluidine 
• 122-52-1 triethyl phosphite 
• 762-04-9 phosphonic acid diethyl ester 
• 31656-92-5 1-azido-2-methyl-benzene 
• 37394-93-7 2-chloro-N-(2-methylphenyl)acetamide 
• 94-69-9 2'-methylformanilide 
• 762-04-9 Diethyl phosphonate 
• 88-72-2 1-methyl-2-nitrobenzene 

Downstream Products

• 86-28-2 N-ethylcarbazole 
• 286435-31-2 C₁₂H₁₇N 
• 1266570-33-5 diethyl 2-methyl-4-(1,3,3-triphenylpropa-1,2-dienyl)phenylphosphoramidate 

Relevant articles and documents

Electrochemical phosphorylation of arenols and anilines leading to organophosphates and phosphoramidates

A practical phosphorylation for generating organophosphates and phosphoramidatesviaelectrochemical dehydrogenative cross-coupling of P(O)H compounds with arenols and anilines is disclosed. This method involves using inorganic iodide salts as both redox catalysts and electrolytes in an undivided cell without the addition of oxidants or bases. A preliminary mechanistic study suggests that radicals are not involved in this process. This method is green and eco-friendly and has good functional group tolerance, high yields and broad substrate scope, with the potential for practical synthesis.

Organophotocatalytic Synthesis of Phosphoramidates

We describe the use of visible light in conjunction with an organic dye for the synthesis of phosphoramidates. Cross dehydrogenative coupling reactions between phosphites and amines are reported using organic dyes and light as catalysts for the first time. It is not only a novel application of organic dyes but also fulfils the requirement of sustainability and green chemistry avoiding the use of chromatographic purification techniques. The product was simply isolated from the reaction mixture via an acid-base work-up procedure, rendering the pure product in good yields.

Iodine catalyzed solvent-free cross-dehydrogenative coupling of arylamines and H-phosphonates for the synthesis of N-arylphosphoramidates under atmospheric conditions

Aerobic oxidative coupling of various arylamines and H-phosphonates to the corresponding N-arylphosphoramidates has been achieved under solvent-free conditions using molecular iodine. This protocol works at room temperature furnishing the corresponding P-