78603-93-7

Basic information

• Product Name: (R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL
• Synonyms: (R)-(-)-2-AMINO-1,1-DIPHENYL-1-PROPANOL;(R)-(+)-2-AMINO-1,1-DIPHENYL-1-PROPANOL;(R)-2-AMINO-1,1-DIPHENYL-1-PROPANOL;(R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL;(R)-2-Amino-1,1-diphenylpropan-1-ol;(R)-2-Amino-1,1-diphenyl-1-propanol,98%e.e.;(2R)-2-amino-1,1-diphenylpropan-1-ol
• CAS NO: 78603-93-7
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227.3
• Product Categories: chiral;Amino Alcohols;Chiral Building Blocks;Organic Building Blocks
• Mol File: 78603-93-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 102-105 °C(lit.)
• Boiling Point: 407.8 °C at 760 mmHg
• Flash Point: 200.4 °C
• Appearance: white to light yellow crystal powder
• Density: 1.112 g/cm³
• Vapor Pressure: 2.21E-07mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 11.25±0.50(Predicted)
• Sensitive: Air Sensitive
• BRN: 3202230
• CAS DataBase Reference: (R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL(78603-93-7)
• EPA Substance Registry System: (R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL(78603-93-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: 8
• Hazardous Substances Data: 78603-93-7(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

InChI:InChI=1/C15H17NO/c1-12(16)15(17,13-8-4-2-5-9-13)14-10-6-3-7-11-14/h2-12,17H,16H2,1H3/t12-/m1/s1

Upstream product

• 108-86-1 bromobenzene 
• 14316-06-4 D-alanine methyl ester hydrochloride 
• 100-58-3 phenylmagnesium bromide 
• 57728-35-5 2-amino-1,1-diphenyl-1-propanol 

Downstream Products

• 1381993-91-4 naphthalene-1-sulfonic acid ((R)-2-hydroxy-1-methyl-2,2-diphenyl-ethyl)-amide 

Relevant articles and documents

PROCESS FOR PREPARING EFAVIRENZ

The invention disclosed a 4 step process for the preparation of Efavirenz, starting from 1,4-dichlorobenzene, and its intermediates.

PROCESS FOR PREPARATION OF EFAVIRENZ BY CYCLISATION

The invention disclosed a process for the preparation of the HIV drug Efavirenz, also known as DMP-266, starting from 1,4-dichlorobenzene, and its intermediates.

Practical copper-catalyzed asymmetric synthesis of chiral chrysanthemic acid esters

Practical copper salicylaldimine complex catalysts have been developed for the asymmetric synthesis of chiral chrysanthemic acid esters by the cyclopropanation reaction of 2,5-dimethyl-2,4-hexadiene with tert-butyl diazoacetate. First, the effects of the substituents on the salicylaldehyde moiety in the copper salicylaldimine complex (copper Schiff base complex) on the catalytic activity and the stereoselectivities were investigated. As a result, a substitution of hydrogen at the 5-position with the nitro group on the salicylaldehyde moiety was found to enhance the catalytic efficiency. In addtition, a combination catalyst of the copper Schiff base complex with Lewis acid was found to also enhance the catalytic efficiency and achieved 90% chemical yield and 91% ee at 20 °C with 0.1 mol % catalyst loading. Furthermore, the asymmetric induction mechanism of the cyclopropanation reaction catalyzed by the copper Schiff base complex was studied using density functional calculations.