787640-34-0

Basic information

• Product Name: 1,2-Pyrrolidinedicarboxylicacid-4-[[((1,1-diMethylethyl)diMethylsilyl]oxy]-2-Methyl-1-(phenylMethyl)ester,(2R,4R)
• Synonyms: 1,2-Pyrrolidinedicarboxylicacid-4-[[((1,1-diMethylethyl)diMethylsilyl]oxy]-2-Methyl-1-(phenylMethyl)ester,(2R,4R)
• CAS NO: 787640-34-0
• Molecular Formula: C₂₀H₃₁NO₅Si
• Mol File: 787640-34-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-Pyrrolidinedicarboxylicacid-4-[[((1,1-diMethylethyl)diMethylsilyl]oxy]-2-Methyl-1-(phenylMethyl)ester,(2R,4R)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Pyrrolidinedicarboxylicacid-4-[[((1,1-diMethylethyl)diMethylsilyl]oxy]-2-Methyl-1-(phenylMethyl)ester,(2R,4R)(787640-34-0)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylicacid-4-[[((1,1-diMethylethyl)diMethylsilyl]oxy]-2-Methyl-1-(phenylMethyl)ester,(2R,4R)(787640-34-0)

Safety Data

• Hazardous Substances Data: 787640-34-0(Hazardous Substances Data)

Usage

Ester derivative

1,2-pyrrolidinedicarboxylic acid
The compound is derived from 1,2-pyrrolidinedicarboxylic acid, which is a four-carbon cyclic amino acid.

Stereocenters

2R and 4R positions
The compound has two chiral centers, which are responsible for its stereochemistry and optical activity.

Chiral building block

Organic synthesis
It is used as a chiral building block in the synthesis of various organic compounds, particularly in the pharmaceutical industry.

Reagent

Chemical reactions
The compound serves as a reagent in various chemical reactions, facilitating the formation of new bonds and structures.

Pharmaceutical industry

Drug production
It is utilized in the pharmaceutical industry for the production of various drug compounds, contributing to the development of new medications.

Development and synthesis

New pharmaceutical drugs and compounds
The compound plays a crucial role in the development and synthesis of new pharmaceutical drugs and compounds, potentially leading to novel treatments and therapies.

Upstream product

• 36901-86-7 cis-hydroxy-D-proline 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 155075-23-3 (2R,4R)-1-benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 51-35-4 4R-4-hydroxyproline 
• 114676-59-4 (2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride 
• 77449-94-6 (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride 
• 444313-67-1 (1R,4R)-5-acetyl-2-oxa-5-azabicyclo[2.2.1]heptan-3-one 
• 501-53-1 benzyl chloroformate 
• 2584-71-6 cis-hydroxy-D-proline 
• 130930-25-5 (R,R)-4-hydroxy-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid 

Downstream Products

• 787640-35-1 (2R,4R)-benzyl 4-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 787640-36-2 (2R,4R)-benzyl 4-(tert-butyldimethylsilyloxy)-2-((methylsulfonyloxy)methyl)pyrrolidine-1-carboxylate 
• 787640-37-3 (1R,4R)-benzyl 2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate 
• 661470-56-0 (1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1194056-54-6 (2R,4R)-benzyl-4-(tert-butyldimethylsilyloxy)-2-formylpyrrolidine-1-carboxylate 
• 1610034-26-8 (2R,4R)-1-benzyl 2-methyl 4-isopropoxypyrrolidine-1,2-dicarboxylate 

Relevant articles and documents

COMPOUNDS

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease.

ANTIBACTERIAL FLUOROQUINOLONE ANALOGS

Compounds having antibacterial activity are disclosed. The compunds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

HETEROCYCLIC CYCLOPENTYL TETRAHYDROISOQUINOLINE AND TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.