79200-57-0

Basic information

• Product Name: (1R,2S,3R,4R)-2,3-DIHYDROXY-4-(HYDROXYMETHYL)-1-AMINOCYCLOPENTANE HYDROCHLORIDE
• Synonyms: (1R,2S,3R,4R)-2,3-DIHYDROXY-4-(HYDROXYMETHYL)-1-AMINOCYCLOPENTANE HYDROCHLORIDE;(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)-1-aminocyclopentaneHCl,(ee);(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)-1-aminocyclopentanehydrochloride,(ee);(1R,2S,3R,4R)-2,3-Dihydroxy-4-(hydroxymethyl)-1-aminocyclopentane hydrochloride, 98% ee;(1R,2S,3R,4R)-2,3-Dihydroxy-4-(hydroxymethyl)-1-aminocyclopentane hydrocloride;(1R,2S,3R,4R)-2,3-Dihydroxy-4-(hydroxymethyl)-1-aminocyclopentane hydrochloride,95%,98% ee;(1R,2S,3R,4R)-2,3-Dihydroxy-4-(hydroxymethyl)-1-aminocyclopentaneHCl;(1R,2S,3R,5R)-3-Amino-5-(hydroxymethyl)-cyclopentane-1,2-diol hydrochloride
• CAS NO: 79200-57-0
• Molecular Formula: C₆H₁₃NO₃*ClH
• Molecular Weight: 183.63
• Mol File: 79200-57-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 300.855°C at 760 mmHg
• Flash Point: 135.752°C
• Appearance: /
• Density: 1.2361 (rough estimate)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.5810 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (1R,2S,3R,4R)-2,3-DIHYDROXY-4-(HYDROXYMETHYL)-1-AMINOCYCLOPENTANE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,3R,4R)-2,3-DIHYDROXY-4-(HYDROXYMETHYL)-1-AMINOCYCLOPENTANE HYDROCHLORIDE(79200-57-0)
• EPA Substance Registry System: (1R,2S,3R,4R)-2,3-DIHYDROXY-4-(HYDROXYMETHYL)-1-AMINOCYCLOPENTANE HYDROCHLORIDE(79200-57-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• Hazardous Substances Data: 79200-57-0(Hazardous Substances Data)

Usage

Description

(1R,2S,3R,4R)-2,3-DIHYDROXY-4-(HYDROXYMETHYL)-1-AMINOCYCLOPENTANE HYDROCHLORIDE is a complex organic compound with a cyclopentane ring structure, featuring four chiral centers and multiple hydroxyl and amino groups. (1R,2S,3R,4R)-2,3-DIHYDROXY-4-(HYDROXYMETHYL)-1-AMINOCYCLOPENTANE HYDROCHLORIDE is characterized by its unique stereochemistry and functional groups, which contribute to its potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
(1R,2S,3R,4R)-2,3-DIHYDROXY-4-(HYDROXYMETHYL)-1-AMINOCYCLOPENTANE HYDROCHLORIDE is used as a reagent in the synthesis of pyridofuran substituted pyrimidine derivatives, which are known as hepatitis C virus (HCV) replication (replicase) inhibitors. These inhibitors play a crucial role in the development of antiviral drugs targeting the replication process of HCV, offering a potential treatment for hepatitis C.
In the synthesis process, the compound serves as a key intermediate, providing the necessary structural elements and functional groups for the formation of the desired pyridofuran substituted pyrimidine derivatives. The chiral centers and hydroxyl groups in the compound contribute to the selectivity and specificity of the synthetic reactions, ensuring the production of the desired enantiomer with the correct stereochemistry.
Overall, (1R,2S,3R,4R)-2,3-DIHYDROXY-4-(HYDROXYMETHYL)-1-AMINOCYCLOPENTANE HYDROCHLORIDE is a valuable compound in the pharmaceutical industry, particularly for the development of antiviral agents against hepatitis C virus. Its unique structural features and potential applications highlight the importance of chiral chemistry and stereoselective synthesis in drug discovery and development.

InChI:InChI=1/C6H13NO3/c7-4-1-3(2-8)5(9)6(4)10/h3-6,8-10H,1-2,7H2/p+1/t3-,4-,5-,6+/m1/s1

Upstream product

• 445469-23-8 (1R,2S,3R,4R)-[2,3-bis-(tert-butyldimethylsilanyloxy)-4-hydroxymethyl-cyclopentyl]carbamic acid tert-butyl ester 
• 79200-54-7 methyl (1S,2R,3S,4R)-4-amino-2,3-dihydroxycyclopentane-1-carboxylate hydrochloride 

Downstream Products

• 1596364-49-6 (1S,2R,3R,5R)-3-(hydroxymethyl)-5-((5-iodo-2-(methylthio)pyrimidin-4-yl)amino)cyclopentane-1,2-diol 
• 1596364-78-1 ((3aR,4R,6R,6aS)-6-((3-(benzo[d]thiazol-2-yl)-6-chloro-2-methylpyridin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol 
• 132342-52-0 ((3aR,4R,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol 
• 1433176-50-1 (1S,2R,3R,5R)-3-(hydroxymethyl)-5-(5-iodo-6-methoxy-2-(methylthio)pyrimidin-4-ylamino)cyclopentane-1,2-diol 
• 1380442-81-8 C₂₄H₂₆N₂O₆S 

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