79286-77-4

Basic information

• Product Name: Esafloxacin
• Synonyms: Esafloxacin;Esafloxacin [inn];Unii-A6nt0I9X0k
• CAS NO: 79286-77-4
• Molecular Formula: C15H17FN4O3
• Molecular Weight: 320.322
• Mol File: 79286-77-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 559.6°C at 760 mmHg
• Flash Point: 292.2°C
• Appearance: /
• Density: 1.427g/cm³
• Vapor Pressure: 2.34E-13mmHg at 25°C
• Refractive Index: 1.621
• CAS DataBase Reference: Esafloxacin(CAS DataBase Reference)
• NIST Chemistry Reference: Esafloxacin(79286-77-4)
• EPA Substance Registry System: Esafloxacin(79286-77-4)

Safety Data

• Hazardous Substances Data: 79286-77-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H17FN4O3/c1-2-19-7-10(15(22)23)12(21)9-5-11(16)14(18-13(9)19)20-4-3-8(17)6-20/h5,7-8H,2-4,6,17H2,1H3,(H,22,23)

Upstream product

• 79286-75-2 7-(3-acetylamino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid 
• 79286-79-6 pyrrolidin-3-amine 
• 79286-73-0 1-ethyl-1,4-dihydro-4-oxo-6-fluoro-7-chloro-1,8-naphthyridine-3-carboxylic acid 

Relevant articles and documents

Naphthyridine derivatives

The present invention provides a 1,8-naphthyridine compound of the formula STR1 wherein R is hydrogen, methyl, ethyl or propyl, and a nontoxic pharmaceutically acceptable salt thereof, and a process for preparing a 1,8-naphthyridine compound of the above formula which comprises (A) reacting a compound of the formula STR2 wherein Y is halogen, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower alkylsulfonyloxy or arylsulfonyloxy, and R1 is hydrogen or lower alkyl, with a compound of the formula STR3 wherein R2 is hydrogen or a protective group for the amino group, and R is as defined above, and when a reaction product in which R1 is lower alkyl and/or R2 is the amino protective group is obtained, treating it with an acid or base, and/or reductively cleaving it, (B) decomposing a compound of the formula STR4 wherein A ? is a fluorine-containing anion, and R1 and R2 are as defined above, and when a reaction product in which R1 is lower alkyl and/or R2 is the amino protective group is obtained, treating it with an acid or base, and/or reductively cleaving it, (C) treating a compound of the formula STR5 wherein R'1 is hydrogen or lower alkyl, R'2 is hydrogen or a protective group for the amino group, provided that R'1 and R'2 are not hydrogen atoms at the same time, and R is as defined above, with an acid or base, and/or reductively cleaving it, and optionally converting the resulting compound to a nontoxic pharmaceutically acceptable salt thereof. The 1,8-naphthyridine compound is useful as an antibacterial agent.