79421-26-4Relevant articles and documents
Benefits of a Dual Chemical and Physical Activation: Direct aza-Michael Addition of Anilines Promoted by Solvent Effect under High Pressure
Fedotova, Alena,Crousse, Benoit,Chataigner, Isabelle,Maddaluno, Jacques,Rulev, Alexander Yu.,Legros, Julien
, p. 10375 - 10379 (2015)
The unique combination of hexafluoroisopropanol (HFIP) employed as solvent and hyperbaric conditions (10-15 kbar) allows unprecedented 1,4-addition of poor nucleophiles, such as aromatic amines, onto sluggish (cumbersome) Michael acceptors without any promoter or workup.