79779-59-2

Basic information

• Product Name: 11-(1-phenoxycarbonyl-4-piperidylene)-5,6-dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridine
• CAS NO: 79779-59-2
• Molecular Weight: 396.489
• Mol File: 79779-59-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 11-(1-phenoxycarbonyl-4-piperidylene)-5,6-dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 11-(1-phenoxycarbonyl-4-piperidylene)-5,6-dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridine(79779-59-2)
• EPA Substance Registry System: 11-(1-phenoxycarbonyl-4-piperidylene)-5,6-dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridine(79779-59-2)

Safety Data

• Hazardous Substances Data: 79779-59-2(Hazardous Substances Data)

Upstream product

• 1885-14-9 phenyl chloroformate 
• 3964-81-6 azatadine 

Relevant articles and documents

N-Substituted 11-(4-piperidylene)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2 -b]pyridines. Antihistamines with no sedating liability

Conversion of the basic tertiary amino function of the potent antihistamine, azatadine (Optimine), to neutral carbamate function results in compounds which retain significant antihistamine activity with little or no CNS effects. In guinea pigs the N-ethoxycarbonyl derivative 4 had the same antihistamine potency as terfenadine, a clinically used non-sedating antihistamine. In mice, 4 was a potent antihistamine while lacking CNS effects. The 8-chloro-N-ethoxycarbonyl 5 (loratadine, Sch 29851) was the most potent antihistamine in the series, had no CNS side effects, and was selected for clinical evaluation.

ANTIHISTAMINIC 11-(4-PIPERIDYLIDENE)-5H-BENZO-[5,6]-CYCLOHEPTA-[1,2-B]-PYRIDINES

11-(4-Piperidylidene)-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridines and their 5,6-dihydro derivatives are disclosed. The compounds are useful as antihistamines with little or no sedative effects.