80041-89-0 Usage
Description
Isopropylboronic acid, also known as 2-hydroxypropane-1,3-diol, is an organic compound with the chemical formula (CH3)2CHOB(OH)2. It is a colorless liquid that is soluble in water and has a weak acidic character. Its boron atom forms a bond with the hydroxyl group, making it a versatile reagent in organic synthesis.
Uses
Used in Chemical Synthesis:
Isopropylboronic acid is used as a reagent in various chemical reactions for the synthesis of complex organic molecules. Its ability to form stable boron-containing intermediates makes it a valuable component in the development of new synthetic routes.
Used in Copper-Promoted Cross-Coupling Reactions:
Isopropylboronic acid is employed as a reagent in copper-promoted cross-coupling reactions, which are widely used in the formation of carbon-carbon bonds. This application allows for the efficient synthesis of various organic compounds, including pharmaceuticals and agrochemicals.
Used in Domino Heck-Suzuki Reactions:
Isopropylboronic acid is used as a reagent in domino Heck-Suzuki reactions, which are a series of consecutive reactions that lead to the formation of complex organic structures. This application enables the rapid assembly of diverse molecular frameworks, facilitating the discovery of new bioactive compounds.
Used in Suzuki-Miyaura Type Couple Reactions:
Isopropylboronic acid is used as a reagent in Suzuki-Miyaura type couple reactions, which are a class of palladium-catalyzed cross-coupling reactions. This application allows for the formation of carbon-carbon bonds between aryl and alkyl halides, providing a powerful tool for the synthesis of various organic compounds.
Used in Alkylation-Hydride Reduction Sequence:
Isopropylboronic acid is used as a reagent in alkylation-hydride reduction sequences, which involve the introduction of an alkyl group followed by a reduction step. This application enables the selective formation of specific functional groups, broadening the scope of organic synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 80041-89-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,0,4 and 1 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 80041-89:
(7*8)+(6*0)+(5*0)+(4*4)+(3*1)+(2*8)+(1*9)=100
100 % 10 = 0
So 80041-89-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H9BO2/c1-3(2)4(5)6/h3,5-6H,1-2H3
80041-89-0Relevant articles and documents
A General C(sp3)-C(sp3) Cross-Coupling of Benzyl Sulfonylhydrazones with Alkyl Boronic Acids
Merchant, Rohan R.,Lopez, Jovan A.
supporting information, p. 2271 - 2275 (2020/03/13)
A general transition-metal-free cross-coupling between benzylic sulfonylhydrazones and 1°, 2°, or 3° alkyl boronic acids is reported. The base-promoted reaction is operationally simple and exhibits a broad substrate scope to forge a variety of alkyl-alkyl bonds, including between sterically encumbered secondary and tertiary sp3-carbons. The ability of this method to simplify retrosynthetic analysis is exemplified by the improved synthesis of multiple medicinally relevant scaffolds.
Tripeptidylpeptidase inhibitors
-
, (2008/06/13)
A compound of formula wherein the substituents are defined as in the specification and salts or hydrates thereof is disclosed as well as a method of treating disorders associated with the inactivation or excessive degradation of cholecystokinin.
