8014-09-3

Basic information

• Product Name: Patchouli oil
• Synonyms: FEMA 2838;PATCHOULI;PATCHOULY OIL;OIL, PATCHOULY;OIL OF PATCHOULI;OIL OF PATCHOULY;Oils,patchouli;Patchoulioildistilled
• CAS NO: 8014-09-3
• Molecular Weight: 0
• EINECS: 282-493-4
• Mol File: 8014-09-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 287 °C(lit.)
• Flash Point: 230 °F
• Appearance: /
• Density: 0.963 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.509(lit.)
• CAS DataBase Reference: Patchouli oil(CAS DataBase Reference)
• NIST Chemistry Reference: Patchouli oil(8014-09-3)
• EPA Substance Registry System: Patchouli oil(8014-09-3)

Safety Data

• WGK Germany: 3
• RTECS: RW7126400
• Hazardous Substances Data: 8014-09-3(Hazardous Substances Data)

Usage

Description

Patchouli oil, derived from the Pogostemon patchouli plant, is known for its astringent, anti-inflammatory, decongestive, and tonic properties. It can act as a stimulant in low doses and a sedative at high doses. The oil is characterized by a strong, sweet, musty, and very persistent fragrance. The leaves of the patchouli plant are dried and fermented before distillation. Patchouli oil may cause allergic reactions in sensitive individuals.

Uses

Used in Skin Care:
Patchouli oil is used as a natural remedy for acne, aged and chapped skin, and skin redness due to its astringent and anti-inflammatory properties.
Used in Perfumery:
Patchouli oil is used as a fragrance ingredient in soaps and cosmetics to impart a long-lasting aroma.
Used in Traditional Medicine:
In Asia, Patchouli oil has been used as a renowned antidote against insect and snake bites.
Used in Aromatherapy:
Patchouli oil can be used in aromatherapy for its calming and sedative effects, especially when used in high doses.
Used in Insect Repellent:
Patchouli oil can be used as a natural insect repellent due to its strong and persistent fragrance.

Chemical constituents

Three terpenoids Germacrene, Patchoulol or patchouli alcohol, Norpatchoulenol found in patchouli oil are responsible for the typical patchouli scent. TLC and HPLC were used to identify the possible chemical markers for evaluating the quality of the crude drug "Pogostemoni herba" (aerial part of P. cablin), a component of Kampo medicines. In addition to the reported patchouli alcohol and 2-hydroxy-6-methyl-3-(4-methylpentanoyl)-4-pyrone, three phenylethanoids (acteoside, isoacteoside, and crenatoside) were isolated from this plant material for the first time.

pharmacology

Antimicrobial Activity Patchouli alcohol, a major component in patchouli oil, and the extract showed higher antibacterial activity than the mixture of β-sitosterol and stigmasterol and 7,3′,4-tri-O-methyleriodictyol.54 The essential oil of P. cablin showed antibacterial activity against periodontopathic bacteria, including Actinobacillus, Capnocytophaga, Fusobacterium, Eikenella. Antiviral activity The anti-influenza A (H2N2) virus activity of patchouli alcohol was studied in vitro, in vivo and in silico. The CC (50) of patchouli alcohol was above 20 μM. It could inhibit influenza virus with an IC (50) of 4.03 ± 0.23 μM. Other Activities Patchouli oil main constituent, patchouli alcohol was found to be toxic and repellent against Formosan subterranean termites.

Essential oil composition

The main known constituents include benzaldehyde, eugenol, cinnamaldehyde, patchouly alcohol (a tricyclic alcohol, C15H260), two hydrocarbons (C15H24), and other minor unidentified components (Burdock, 1997).

Safety Profile

Low toxicity by ingestion and skin contact. A skin irritant. A combustible liquid. When heated to decompositionit emits acrid smoke and irritating vapors.