80146-85-6 Usage
Description
EC 2.3.2.13, also known as transglutaminase, is an enzyme that plays a crucial role in various biological processes, including protein cross-linking, blood clotting, and skin barrier formation. It catalyzes the acyl transfer reaction between a γ-carboxyamide group of a peptide-bound glutamine donor and a primary amine acceptor, such as lysine, leading to the formation of isopeptide bonds. This enzyme has gained significant attention due to its potential applications in various fields.
Uses
Used in Skin Care Industry:
EC 2.3.2.13 is used as an enzyme activator for enhancing the skin's physiological functions. It helps improve skin elasticity, hydration, and barrier function, making it a valuable ingredient in cosmetic products.
Used in Medical Research:
In the medical field, EC 2.3.2.13 is used as a research tool for studying its role in various diseases, such as Huntington's disease and Alzheimer's disease. It aids in understanding the underlying mechanisms and potential therapeutic targets for these conditions.
Used in Diagnostic Assays:
EC 2.3.2.13 is also used in the development of nonradioactive dot blot assays for transglutaminase activity. This allows for a safer and more efficient method of measuring enzyme activity, which can be crucial for diagnostic and research purposes.
Biochem/physiol Actions
Transglutaminase from guinea pig liver consists of a single polypeptide chain of 691 amino acid residues. It has six potential glycosylation sites (Asn-X-Ser or Asn-X-Thr), but it is not glycosylated. The molecular mass is approximately 76.6 kDa. It is calcium dependent and has several calcium binding sites. The enzyme is inhibited by iodoacetamide and N-ethylmaleimide in the presence of calcium. It catalyzes the incorporation of small molecular weight amines into γ-glutamine sites of proteins. In the absence of small molecular weight amines, it catalyzes the cross linking of proteins that results in the formation of γ-glutamyl-ε-lysine side chain peptides. Liver transglutaminase is a nonzymogenic enzyme.
Check Digit Verification of cas no
The CAS Registry Mumber 80146-85-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,1,4 and 6 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 80146-85:
(7*8)+(6*0)+(5*1)+(4*4)+(3*6)+(2*8)+(1*5)=116
116 % 10 = 6
So 80146-85-6 is a valid CAS Registry Number.
