802-31-3 Usage
Description
9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E,17Z-TRIEN-1-OIC ACID, also known as Prostaglandin E3 (PGE3), is a bioactive lipid compound derived from the metabolism of eicosapentaenoic acid through the cyclooxygenase (COX) pathway. It is a member of the prostaglandin family and plays a crucial role in various physiological processes, including the regulation of inflammation, blood flow, and pain perception.
Uses
Used in Ophthalmology:
PGE3 is used as a therapeutic agent in ophthalmology for the treatment of ocular hypertension and glaucoma. In human ocular tissue, it constitutes 2.4% of the COX products formed. When applied to the eyes of a rabbit, a 1 μg dose of PGE3 effectively reduces intraocular pressure from 21 mmHg to about 17 mmHg, demonstrating its potential in managing increased intraocular pressure associated with glaucoma.
Used in Anti-inflammatory Applications:
PGE3 exhibits anti-inflammatory properties and is used to alleviate inflammation and pain in various conditions. It modulates the immune response by inhibiting the production of pro-inflammatory cytokines and promoting the release of anti-inflammatory mediators, making it a valuable compound in the treatment of inflammatory disorders.
Used in Cardiovascular Health:
PGE3 plays a role in maintaining cardiovascular health by promoting vasodilation and inhibiting platelet aggregation. It helps regulate blood flow and prevents the formation of blood clots, reducing the risk of cardiovascular diseases such as atherosclerosis, hypertension, and thrombosis.
Used in Gastrointestinal Protection:
PGE3 is used to protect the gastrointestinal mucosa and promote healing in conditions like ulcers and inflammatory bowel disease. It stimulates the production of mucus and bicarbonate ions, which protect the stomach lining from acid damage, and inhibits the secretion of gastric acid, reducing inflammation and promoting tissue repair.
Check Digit Verification of cas no
The CAS Registry Mumber 802-31-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,0 and 2 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 802-31:
(5*8)+(4*0)+(3*2)+(2*3)+(1*1)=53
53 % 10 = 3
So 802-31-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1
