804-63-7

Basic information

• Product Name: QUININE SULFATE
• Synonyms: Quinine sulfate(2:1);6’-methoxy-cinchonan-9-o(8alpha,9theta)-cinchonan-9-osulfate(2:1)(salt);Cinchonan-9-ol,6’-methoxy-,(8.alpha.,9R)-,sulfate(2:1)(salt);legatrin;quininehydrogensulfate;QUININE HEMISULFATE;QUININE BISULFATE;QUININE SULFATE
• CAS NO: 804-63-7
• Molecular Formula: C40H50N4O8S
• Molecular Weight: 746.91
• EINECS: 212-359-2
• Product Categories: Organics
• Mol File: 804-63-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 235.2°C
• Boiling Point: 911.6 °C at 760 mmHg
• Flash Point: 505.1 °C
• Appearance: /
• Density: 1.0807 (rough estimate)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• CAS DataBase Reference: QUININE SULFATE(CAS DataBase Reference)
• NIST Chemistry Reference: QUININE SULFATE(804-63-7)
• EPA Substance Registry System: QUININE SULFATE(804-63-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 1544
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 804-63-7(Hazardous Substances Data)

Usage

Description

Quinine sulfate is a white crystalline compound derived from the bark of the cinchona tree. It is a potent antimalarial drug, known for its bitter taste and effectiveness in treating malaria caused by Plasmodium falciparum.

Uses

Used in Pharmaceutical Industry:
Quinine sulfate is used as an antimalarial drug for the treatment of chloroquine-resistant strains of P. falciparum, a type of malaria parasite. It is effective in reducing the severity and duration of the disease, although it may not always provide a complete cure.
Used in Malaria Treatment:
Quinine sulfate is used as a therapeutic agent for the treatment of malaria, particularly in cases where other drugs have failed or are not suitable. It is administered in combination with other antimalarial drugs to increase the chances of a successful treatment and to reduce the risk of drug resistance.

World Health Organization (WHO)

Quinine is an important drug in the treatment of multi- drugresistant forms of malaria. Its use in nocturnal leg muscle cramps, a benign and self-limiting condition, is connected with unjustified risks. Quinine is listed in the WHO Model List of Essential Drugs for treatment of malaria.

Safety Profile

Human poison by ingestion. Human systemic effects by ingestion: acuity changes, blood agranulocytosis, fibrous hepatitis, flaccid paralysis without anesthesia, motor activity changes, mydriasis (pupillary dilation), nausea or vomiting, tinnitus, visual field changes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NO,. See also QUININE.

Purification Methods

Crystallise it from water and dry it at 110o. [Beilstein 23 H 522, 23 I 168, 23 II 420, 23 III/IV 3269, 23 V 396.]

InChI:InChI=1/2C20H24N2O2.H2O4S/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4)/t2*13-,14-,19-,20+;/m00./s1

Downstream Products

• 86-68-0 6-methoxyquinoline-4-carboxylic acid