80651-76-9

Basic information

• Product Name: Sanggenon C
• Synonyms: Sanggenon C;(5aR,10aS)-2-[6β-(2,4-Dihydroxybenzoyl)-5α-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexene-1β-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-butenyl)-11H-benzofuro[3,2-b][1]benzopyran-11-one;2-[(1S)-6β-(2,4-Dihydroxybenzoyl)-5α-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexene-1β-yl]-5a,10a-dihydro-1,3,8,10aβ-tetrahydroxy-5aβ-(3-methyl-2-butenyl)-11H-benzofuro[3,2-b][1]benzopyran-11-one;Sanggenone C;(5aR,10aS)-2-[(1S,5S,6R)-6-(2,4-Dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-11H-benzofuro[3,2-b][1]benzopyran-11-one;sanggenone
• CAS NO: 80651-76-9
• Molecular Formula: C₄₀H₃₆O₁₂
• Molecular Weight: 708.712
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;reagent;standard substance
• Mol File: 80651-76-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 995.5 °C at 760 mmHg
• Flash Point: 311.5 °C
• Appearance: /
• Density: 1.512
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.726
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Acetone (Slightly), Methanol (Slightly)
• PKA: 6.61±0.60(Predicted)
• CAS DataBase Reference: Sanggenon C(CAS DataBase Reference)
• NIST Chemistry Reference: Sanggenon C(80651-76-9)
• EPA Substance Registry System: Sanggenon C(80651-76-9)

Safety Data

• Hazardous Substances Data: 80651-76-9(Hazardous Substances Data)

Usage

Description

Sanggenon C is a flavonoid found in mulberry bark with diverse biological activities, including anti-inflammatory, pro-apoptotic, and bone mineralization properties.

Uses

Used in Pharmaceutical Industry:
Sanggenon C is used as an anti-inflammatory agent for inhibiting TNF-αor IL-1β-induced polymorphonuclear leukocyte adhesion to human synovial cells and NF-κB activation in HSCs.
Used in Cancer Therapy:
Sanggenon C is used as a pro-apoptotic agent for inducing apoptosis and production of reactive oxygen species in HT-29 cells, decreasing cell viability, and reducing tumor growth in an HT-29 mouse xenograft model.
Used in Bone Health:
Sanggenon C is used as a bone mineralization agent for increasing vertebrate column bone mineralization in a zebrafish model of prednisone-induced osteoporosis.
Used in Cardiac Health:
Sanggenon C is used as a cardiac protective agent for attenuating cardiac hypertrophy and fibrosis, and reducing activation of nuclear factor of activated T cells 2 in a mouse model of pressure overload-induced cardiac hypertrophy.
Used in Biochemical Research:
Sanggenon C is used as a cytotoxic agent against human oral tumor cell lines (HSC-2 and HSG) and as an inhibitor of protein tyrosine phosphatase 1B.

InChI:InChI=1/C40H36O12/c1-18(2)10-11-39-27-9-6-22(43)16-31(27)52-40(39,50)38(49)35-32(51-39)17-30(46)34(37(35)48)26-13-19(3)12-25(23-7-4-20(41)14-28(23)44)33(26)36(47)24-8-5-21(42)15-29(24)45/h4-10,13-17,25-26,33,41-46,48,50H,11-12H2,1-3H3/t25-,26+,33-,39?,40?/m1/s1