807-38-5 Usage
Description
6-alpha,9-alpha-difluoro-11-beta,16-alpha,17-alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione is a complex steroid molecule with multiple hydroxyl and fluoro substitutions. It is a derivative of the steroid hormone pregnane, which has been modified to possess unique properties and potential therapeutic applications.
Uses
Used in Pharmaceutical Industry:
6-alpha,9-alpha-difluoro-11-beta,16-alpha,17-alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione is used as a medication for treating various skin conditions. It is particularly effective in addressing symptoms such as itching, redness, dryness, crusting, scaling, inflammation, and discomfort associated with these conditions.
Used in Medicinal Chemistry Research:
As a derivative of Fluocinolone Acetonide (F455800), 6-alpha,9-alpha-difluoro-11-beta,16-alpha,17-alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione serves as a valuable compound in medicinal chemistry research. It can be further studied and modified to develop new drugs with improved therapeutic properties and reduced side effects.
Note: The provided materials do not mention any specific applications for 6-alpha,9-alpha-difluoro-11-beta,16-alpha,17-alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione other than its use as a medication to treat skin conditions. The information on its use in the pharmaceutical industry and medicinal chemistry research is inferred based on its relationship to Fluocinolone Acetonide.
Check Digit Verification of cas no
The CAS Registry Mumber 807-38-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,0 and 7 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 807-38:
(5*8)+(4*0)+(3*7)+(2*3)+(1*8)=75
75 % 10 = 5
So 807-38-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H26F2O6/c1-18-4-3-10(25)5-13(18)14(22)6-12-11-7-15(26)21(29,17(28)9-24)19(11,2)8-16(27)20(12,18)23/h3-5,11-12,14-16,24,26-27,29H,6-9H2,1-2H3/t11-,12-,14-,15+,16-,18-,19-,20-,21-/m0/s1
807-38-5Relevant articles and documents
ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF
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Paragraph 442; 579, (2021/10/30)
The invention provides anti-VISTA antibody drug conjugates which may be used for targeted delivery of anti-inflammatory agents such as steroids to immune cells, e.g., myeloid cells. The invention also provides methods of using anti-VISTA antibody drug conjugates in the treatment of inflammatory and/or autoimmune conditions and/or for alleviating the toxicity of anti-inflammatory agents such as steroids.
ANTI-CD40 ANTIBODY DRUG CONJUGATES
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Paragraph 00143, (2019/06/17)
Provided herein are anti-CD40 antibody drug conjugates comprising a radical of Formula (I), wherein R1, R2, and R3 are as defined herein. Further provided are anti-CD40 antibody drug conjugates of Formula (II), wherein Z, R, AA1, AA2, AA3, m, p, q, n, w, R1, R2, and R3 are as defined herein. Further provided are pharmaceutical compositions and kits thereof, and methods of using same.
Kilogram-scale synthesis of an inhaled corticosteroid
Knight, Craig J.,Millan, David S.,Moses, Ian B.,Robin, Aurelie A.,Selby, Matthew D.
experimental part, p. 697 - 703 (2012/08/07)
The development and implementation of a safe and scalable process for the manufacture of corticosteroid PF-4714224 (1) is described. Initial routes used to synthesise analogues from this series directly from fluocinolone acetonide (2) were unsuitable for large-scale use. Key aspects of the route are the efficient and simple method for the preparation of the steroid tetraol (6), acetal formation by reaction of the tetraol with a bisulphite adduct (12), and isolation of the product by sequential recrystallisations.