80783-57-9Relevant articles and documents
Preparation method of trifluoromethyl aryl thioether
-
Paragraph 0027; 0033-0035, (2021/02/20)
The invention discloses a preparation method of trifluoromethyl aryl thioether, and belongs to the field of chemicals for daily use in chemical industry. Aryl sulfinate and trifluoromethyl trimethyl silane are used as substrates, no transition metal catalyst is needed, and trifluoromethyl aryl thioether is obtained through reaction under the action of an additive, an oxidizing agent and alkali. The reaction can be carried out in a room-temperature environment, the reaction is green, simple and convenient, the reaction yield is as high as 55%, and a new approach of a trifluoromethylthiolation indirect method is provided in the field of fluorine chemistry; the obtained product has wide application in the fields of medicines, pesticides and materials.
Metal-Free Trifluoromethylthiolation of Arylazo Sulfones
Li, Ankun,Li, Yuxuan,Liu, Junjie,Chen, Jingqi,Lu, Kui,Qiu, Di,Fagnoni, Maurizio,Protti, Stefano,Zhao, Xia
, p. 1292 - 1299 (2021/01/14)
A visible-light-driven protocol for the synthesis of aryl trifluoromethyl thioethers under photocatalyst- and metal-free conditions has been pursued. The procedure exploits the peculiar properties of arylazo sulfones (having electron-rich or electron-poor substituents on the (hetero)aromatic ring) as photochemical precursors of aryl radicals and S-trifluoromethyl arylsulfonothioates as easy-to-handle trifluoromethylthiolating agents.
Trifluoromethyl Sulfoxides: Reagents for Metal-Free C?H Trifluoromethylthiolation
Carlton, C. Grace,McDouall, Joseph J. W.,Perry, Gregory J. P.,Procter, David J.,Tayu, Masanori,Wang, Dong
supporting information, p. 15918 - 15922 (2020/07/20)
Trifluoromethyl sulfoxides are a new class of trifluoromethylthiolating reagent. The sulfoxides engage in metal-free C?H trifluoromethylthiolation with a range of (hetero)arenes. The method is also applicable to the functionalization of important compound classes, such as ligand derivatives and polyaromatics, and in the late-stage trifluoromethylthiolation of medicines and agrochemicals. The isolation and characterization of a sulfonium salt intermediate supports an interrupted Pummerer reaction mechanism.
