81367-73-9Relevant articles and documents
Farnesyl Derivatives of Rigid Carboxylic Acids-Inhibitors of ras-Dependent Cell Growth
Marciano, Daniella,Ben-Baruch, Gilad,Marom, Michal,Egozi, Yaakov,Haklai, Roni,Kloog, Yoel
, p. 1267 - 1272 (1995)
Inhibitors of the enzyme that methylates ras proteins, the prenylated protein methyltransferase (PPMTase), are described.They are fernesyl derivatives of rigid carboxylic acids that recognize the farnesylcysteine recognition domain of the enzyme but do no