814-75-5 Usage
Description
3-BROMO-2-BUTANONE, also known as Methyl Ethyl Ketone (MEK), is an organic compound with the chemical formula C4H8OBr. It is a colorless liquid with a pungent odor and is soluble in water. It is commonly used as a solvent in various industries due to its ability to dissolve a wide range of substances.
Used in Chemical Industry:
3-BROMO-2-BUTANONE is used as a solvent for the preparation of o-isopropyl S-3-oxobutan-2-yl dithiocarbonate. 3-BROMO-2-BUTANONE is synthesized by reacting 3-BROMO-2-BUTANONE with potassium o-isopropylxanthate. The resulting product is then treated with sulfuric acid to yield 4,5-dimethyl-1,3-dithiol-2-one, which has potential applications in the synthesis of pharmaceuticals and other organic compounds.
Used in Pharmaceutical Industry:
3-BROMO-2-BUTANONE plays a crucial role in the synthesis of various pharmaceutical compounds. The intermediates obtained from its reactions, such as o-isopropyl S-3-oxobutan-2-yl dithiocarbonate and 4,5-dimethyl-1,3-dithiol-2-one, can be further modified to produce active pharmaceutical ingredients. These compounds can be used in the development of drugs for the treatment of various diseases and medical conditions.
Used in Research and Development:
3-BROMO-2-BUTANONE is also used as a research chemical in academic and industrial laboratories. Its reactivity and ability to form a wide range of derivatives make it a valuable tool for studying chemical reactions and developing new synthetic methods. Researchers can use 3-BROMO-2-BUTANONE to explore its potential applications in various fields, such as materials science, polymer chemistry, and drug discovery.
Synthesis Reference(s)
Tetrahedron Letters, 25, p. 3369, 1984 DOI: 10.1016/S0040-4039(01)81387-3
Check Digit Verification of cas no
The CAS Registry Mumber 814-75-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,1 and 4 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 814-75:
(5*8)+(4*1)+(3*4)+(2*7)+(1*5)=75
75 % 10 = 5
So 814-75-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H7BrO/c1-3(5)4(2)6/h3H,1-2H3/t3-/m0/s1
814-75-5Relevant articles and documents
Peterson,Indelicato
, p. 531 (1970)
Preparation method of 3-methyl-3-penten-2-one
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Paragraph 0012-0016, (2019/01/08)
The invention discloses a preparation method of 3-methyl-3-penten-2-one. The preparation method comprises the following steps: with butanone as a raw material, performing 3-position halogenation to obtain 3-halobutanone (1), then performing a ketalation reaction to obtain 3-halobutanonediol (2), then performing a Grignard reaction to obtain a Grignard reagent, performing nucleophilic addition on the Grignard reagent and acetaldehyde, and performing intramolecular dehydration under the conditions of acid catalysis and heating to obtain a target product, namely the 3-methyl-3-penten-2-one (3). The preparation method has the advantages of easy obtainment of the raw material, a wide raw material source, simpleness, low preparation cost and suitability for industrial production; by the preparation method, the problems of high preparation cost and difficult industrial production in the prior art are solved.
Design, synthesis and antifungal activity of novel furancarboxamide derivatives
Wen, Fang,Jin, Hong,Tao, Ke,Hou, Taiping
, p. 244 - 251 (2016/05/24)
Twenty-seven novel furancarboxamide derivatives with a diphenyl ether moiety were synthesized and evaluated for their antifungal activity against Rhizoctonia solani, Botrytis cirerea, Valsa Mali and Sphaceloma ampelimum. Antifungal bioassay results indicated that most compounds had good or excellent fungicidal activities for R. solani and S. ampelimum at 20 mg L-1. Among synthesized compounds, compound 18e showed a greater inhibitory effect against S. ampelimum, with half maximal effective concentration (EC50) values of 0.020 mg L-1. This strong activity rivals currently used commercial fungicides, such as Boscalid and Carbendazim, and has great potential as a lead compound for future development of novel fungicides.