82050-00-8Relevant articles and documents
Stereospecific Ring Opening and Cycloisomerization of Aziridines with Propargylamines: Synthesis of Functionalized Piperazines and Tetrahydropyrazines
Das, Bijay Ketan,Pradhan, Sourav,Punniyamurthy, Tharmalingam
supporting information, p. 4444 - 4448 (2018/08/07)
Stereospecific Cu-catalyzed nucleophilic ring opening of N-sulfonylaziridines with propargylamines and subsequent hydroamination afford piperazines, which leads to double-bond isomerization to furnish tetrahydropyrazines. Optically active aziridines can be cross-coupled with high enantiomeric purities (>98% ee).
Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines
McNamara,Berman,Fry,Werbel
, p. 2045 - 2051 (2007/10/02)
The synthesis and biological activity of two series of nonclassical thymidylate synthase (TS) inhibitors are described. The first is a series of 10-propargyl-5.8-dideazafolic acid derivatives (10a-j) and the second is a series of the analogous 2-desamino