824-53-3

Basic information

• Product Name: (2-bromo-4-methylphenyl)methanol
• Synonyms: (2-bromo-4-methylphenyl)methanol;2-Bromo-4-methylbenzyl alcohol;Benzenemethanol, 2-bromo-4-methyl-
• CAS NO: 824-53-3
• Molecular Formula: C₈H₉BrO
• Molecular Weight: 201.06046
• Mol File: 824-53-3.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-bromo-4-methylphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-bromo-4-methylphenyl)methanol(824-53-3)
• EPA Substance Registry System: (2-bromo-4-methylphenyl)methanol(824-53-3)

Safety Data

• Hazardous Substances Data: 824-53-3(Hazardous Substances Data)

Usage

Description

(2-bromo-4-methylphenyl)methanol is an organic compound characterized by the presence of a bromine atom at the 2nd position and a methyl group at the 4th position on a phenyl ring, with a hydroxymethyl group attached to the benzylic carbon. This unique structure endows it with specific chemical properties that make it suitable for various applications in the chemical and pharmaceutical industries.

Uses

Used in Pharmaceutical Industry:
(2-bromo-4-methylphenyl)methanol is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Chemical Industry:
(2-bromo-4-methylphenyl)methanol is used as a chemical intermediate in the preparation of 6,7-Dihydro-5H-diphenyl[a,c]cyclohepten-5-one compounds. These compounds are important in the synthesis of various organic molecules and can be used as precursors for the development of new chemical products.

Upstream product

• 7697-27-0 2-bromo-4-methylbenzoic acid 
• 824-54-4 2-bromo-4-methylbenzaldehyde 
• 88174-23-6 2,6-dibromo-4-methylbenzaldehyde 

Downstream Products

• 1300038-68-9 2-(2-bromo-4-methylbenzyl)-2-nitrocyclohexanone 
• 1300038-74-7 2-(2-bromo-4-methylbenzyl)-2-nitrocycloheptanone 
• 1300038-81-6 2-(2-bromo-4-methylbenzyl)-2-nitrocyclooctanone 
• 1300038-61-2 2-bromo-1-iodomethyl-4-methylbenzene 
• 147542-02-7 2-bromo-1-(chloromethyl)-4-methylbenzene 

Relevant articles and documents

PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES.

Described herein are pyrido-pyrimidinone and pteridinone compounds or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods treating cancer, alone and in combination with other therapeutic agents.

Morita-Baylis-Hillman Reaction of β,β-Disubstituted Enones: An Enantioselective Organocatalytic Approach for the Synthesis of Cyclopenta[b]annulated Arenes and Heteroarenes

The first enantioselective organocatalytic intramolecular Morita-Baylis-Hillman (MBH) reaction of sterically highly demanding β,β-disubstituted enones is presented. The MBH reaction of β,β-disubstituted-α,β-unsaturated electron-withdrawing systems was previously considered to be unfeasible. Towards this end, designer substrates, which under simple and practical reaction conditions generate a variety of cyclopenta[b]annulated arenes and heteroarenes in excellent enantiopurities and near-quantitative yields in remarkably short reaction times, are described. The reason for the unusually facile nature of this reaction is attributed to the synergy guided and entropically favored intramolecular reaction. Further, this strategy provides easy access to a substantial number of bioactive natural products and pharmaceutically significant compounds.

N-protected 1,2-oxazetidines as a source of electrophilic oxygen: Straightforward access to benzomorpholines and related heterocycles by using a reactive tether

A hitherto unknown reactivity of a strained four-membered heterocycle, 1,2-oxazetidine, is reported. When reacted with organometallic compounds, this reagent provides electrophilic oxygen with a nitrogen-terminated two-carbon-atom tether. The synthetic versatility of the products obtained was demonstrated in various transformations, leading to efficient synthesis of six-, seven-, and eight-membered heterocyclic systems of pharmaceutical importance. Open and then close: The O-selective ring-opening reaction of 1,2-oxazetidines with organometallic compounds provides tethered phenol derivatives that can be used to access six-, seven-, and eight-membered heterocyclic systems in only a few steps (see scheme; Ts=tosyl).