82499-60-3

Basic information

• Product Name: ((4-bromobenzyl)oxy)acetic acid
• Synonyms: ((4-bromobenzyl)oxy)acetic acid
• CAS NO: 82499-60-3
• Molecular Formula: C₉H₉BrO₃
• Molecular Weight: 245.07
• Mol File: 82499-60-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 386.9°Cat760mmHg
• Flash Point: 187.8°C
• Appearance: /
• Density: 1.571g/cm³
• Vapor Pressure: 1.12E-06mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: ((4-bromobenzyl)oxy)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: ((4-bromobenzyl)oxy)acetic acid(82499-60-3)
• EPA Substance Registry System: ((4-bromobenzyl)oxy)acetic acid(82499-60-3)

Safety Data

• Hazardous Substances Data: 82499-60-3(Hazardous Substances Data)

Usage

Description

((4-Bromobenzyl)oxy)acetic acid is a chemical compound with the molecular formula C9H9BrO3, consisting of a 4-bromobenzyl group attached to an acetic acid molecule through an oxygen atom. It belongs to the class of organic compounds known as phenol esters and is characterized by its wide range of applications in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
((4-Bromobenzyl)oxy)acetic acid is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into the molecular structure of drugs, enhancing their therapeutic properties and effectiveness.
Used in Chemical Industry:
((4-Bromobenzyl)oxy)acetic acid is used as a building block in the production of various organic compounds, contributing to the development of new chemical entities with potential applications in different fields.
Used in Research and Development:
((4-Bromobenzyl)oxy)acetic acid is used as a reagent in organic synthesis and in the research and development of new compounds with potential medicinal properties, facilitating the discovery and innovation of novel therapeutic agents.

InChI:InChI=1/C9H9BrO3/c10-8-3-1-7(2-4-8)5-13-6-9(11)12/h1-4H,5-6H2,(H,11,12)

Upstream product

• 64-69-7 Iodoacetic acid 
• 873-75-6 4-bromobenzenemethanol 
• 79-11-8 chloroacetic acid 
• 1454928-09-6 tert-butyl 2-((4-bromobenzyl)oxy)acetate 
• 79-08-3 bromoacetic acid 
• 589-17-3 p-bromobenzyl chloride 
• 256413-71-5 ethyl 2-(4-bromobenzyloxy)acetate 

Downstream Products

• 1454925-76-8 2-(4'-(((1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methoxy)methyl)-[1,1'-biphenyl]-3-yl)acetic acid 
• 1454928-11-0 3-(((4-bromobenzyl)oxy)methyl)-1-(4-(tert-butyl)benzyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one 
• 1454928-12-1 ethyl 2-(4'-(((1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methoxy)methyl)-[1,1 '-biphenyl]-3-yl)acetate 
• 1454928-10-9 2-(2-((4-bromobenzyl)oxy)acetyl)-1-(4-(tert-butyl)benzyl)-N-ethylhydrazinecarboxamide 
• 943742-51-6 benzyl 3-(2-(4-bromobenzyloxy)acetamido)benzylcarbamate 

Relevant articles and documents

Glycerol conversion to high-value chemicals: The implication of unnatural α-amino acid syntheses using natural resources

Glycerol derivatives are an important class of compounds, which have great applications as basic structural building blocks in organic synthesis. O-Benzylglycerol was oxidised to produce a high-value compound in high yield using a NaOtBu-O2 system. Furthermore, the synthetic utility of the resulting product was demonstrated by its transformation into unnatural α-amino acids, thus showing the valorisation of glycerol biomass.

TRIAZOLONE COMPOUNDS AND USES THEREOF

The invention disclosed herein is directed to compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of Formula (I), or a pharmaceutically acceptable salt thereof. The invention disclosed herein is also directed to methods of treating prostate, breast, ovarian, liver, kidney, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention disclosed herein is further directed to methods of treating prostate, breast, colon, pancreatic, chronic lymphocytic leukemia, melanoma and other cancers comprising administration of a of a therapeutically effective amount of a selective PPARα antagonist. The compounds and pharmaceutical compositions of the invention are also useful in the treatment of viral infections, such as HCV infections and HIV infections. The invention disclosed herein is also directed to a methods of preventing the onset of and/or recurrence of acute and chronic myeloid leukemia, as well as other cancers, comprising administration of a of a therapeutically effective amount of a selective PPARα antagonist.

MACROCYCLIC FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS

The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, thereof, wherein the variables A, B, L, M, W, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein. These compounds are selective inhibitors of the serine protease coagulation factor VIIa which can be used as medicaments.