82520-37-4

Basic information

• Product Name: 3-METHOXY-4'-METHYLBENZOPHENONE
• Synonyms: 3-METHOXY-4'-METHYLBENZOPHENONE;(3-METHOXYPHENYL)(4-METHYLPHENYL)METHANONE;OTAVA-BB 1044025
• CAS NO: 82520-37-4
• Molecular Formula: C₁₅H₁₄O₂
• Molecular Weight: 226.27
• Product Categories: Aromatics
• Mol File: 82520-37-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 145-150°C at 0.6 mm Hg
• Flash Point: 169.8°C
• Appearance: /
• Density: 1.088g/cm³
• Vapor Pressure: 8.06E-06mmHg at 25°C
• Refractive Index: 1.563
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: 3-METHOXY-4'-METHYLBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXY-4'-METHYLBENZOPHENONE(82520-37-4)
• EPA Substance Registry System: 3-METHOXY-4'-METHYLBENZOPHENONE(82520-37-4)

Safety Data

• Hazardous Substances Data: 82520-37-4(Hazardous Substances Data)

Usage

Description

3-Methoxy-4'-methylbenzophenone, with the chemical formula C14H12O2, is an organic compound characterized by a benzophenone structure with a methoxy group at the 3-position and a methyl group at the 4'-position. It is a viscous yellow oil at room temperature and is known for its utility in various organic synthesis processes.

Uses

Used in Organic Synthesis:
3-Methoxy-4'-methylbenzophenone is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a valuable building block for the creation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-Methoxy-4'-methylbenzophenone is utilized as a precursor for the development of new drugs. Its chemical properties enable it to be modified and incorporated into complex molecular structures, contributing to the discovery of novel therapeutic agents.
Used in Agrochemical Industry:
3-Methoxy-4'-methylbenzophenone also finds application in the agrochemical sector, where it serves as a starting material for the synthesis of pesticides and other crop protection agents. Its versatility in organic synthesis facilitates the production of effective and targeted agrochemicals.
Used in Specialty Chemicals:
In the specialty chemicals market, 3-Methoxy-4'-methylbenzophenone is employed as a component in the formulation of various products, such as dyes, pigments, and fragrances. Its chemical structure lends itself to the creation of unique and valuable compounds for diverse applications.

Preparation

Complex preparation: Tandem catalysis access to ketones from aldehydes and –arylboronic acids via rhodium-catalyzed addition/oxidation.

InChI:InChI=1/C15H14O2/c1-11-6-8-12(9-7-11)15(16)13-4-3-5-14(10-13)17-2/h3-10H,1-2H3

Upstream product

• 42498-32-8 N-tert-butyl-4-methylbenzamide 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 49834-28-8 N-(tert-butyl)-3-methoxybenzamide 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 586-38-9 3-Methoxybenzoic acid 
• 66117-64-4 di(p-tolyl)borinic acid 
• 201230-82-2 carbon monoxide 
• 624-31-7 4-tolyl iodide 
• 10365-98-7 3-methoxyphenylboronic acid 
• 106-38-7 para-bromotoluene 
• 1711-05-3 m-anisoyl chloride 
• 104-87-0 4-methyl-benzaldehyde 
• 5142-75-6 tri(p-tolyl)bismuth 
• 108-88-3 toluene 

Downstream Products

• 1312552-03-6 4-[(10-allyl-9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide 
• 1312552-02-5 4-[(10-allyl-9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide 
• 1312555-08-0 4-[(9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide 
• 1312554-93-0 4-[(10-benzyl-9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide 
• 150428-54-9 BWB 373 
• 156727-75-2 SNC 79 
• 156727-71-8 SNC 67 
• 156727-74-1 (+)-4-[(αR)-α-(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamide 
• 156727-72-9 SNC 83 
• 150428-54-9 SNC 88 
• 150428-54-9 SNC 89 
• 155836-50-3 4-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide 
• 150428-54-9 SNC 85 
• 186094-10-0 4-[Chloro-(3-methoxy-phenyl)-methyl]-N,N-diethyl-benzamide 

Relevant articles and documents

Highly efficient synthesis of aryl ketones by PEPPSI-palladium catalyzed acylative Suzuki coupling of amides with diarylborinic acids

An improved acylative cross-coupling of various N-methyl-N-tosyl amides with diarylborinic acids for synthesis of aryl ketones is developed. In most cases, aryl ketones could be obtained in excellent yields by using 1 mol% 2,6-diisopropylphenylimidazolylidene and 3-chloropyridine co-supported palladium chloride as catalyst in the presence of 3 equiv. K2CO3 as base in refluxing THF. The readily prepared and cost-effective substrates, N-methyl-N-tosylamides and diarylborinic acids, and the commercially available catalyst system promise a practical and efficient access to aryl ketones.

PHARMACEUTICAL COMPOUNDS

Diazapolycyclic compounds having affinity for the opioidergic receptors, preferably for the delta opioidergic receptors, with central and/or peripheral activity, having formula: [in-line-formulae]A1-D1-T1??(I)[/in-line-formulae] wherein: A1 is a group of formula (II): wherein: R1 is phenyl wherein one of the ring hydrogen atoms is substituted with a group selected from C(O)R′, C(O)OR′, C(O)NHR′ or C(O)NR3R4, R′, R3 and R4, being as defined in the application; R2 is phenyl, optionally substituted D1 is a diazapolycyclic group T1 is a group selected from H, alkyl, alkenyl, alkynyl and from the following optionally substituted groups: cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl or heteroarylalkyl, and their hydrates and solvates and pharmaceutically acceptable salts.

SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATIONS AND USES

The present invention relates to polysubstituted imidazolone derivatives, to the pharmaceutical compositions comprising them and to the therapeutic uses thereof in the human and animal health fields. The present invention also relates to a process for preparing these derivatives.