826-39-1 Usage
Description
Mecamylamine hydrochloride, also known as Inversine, is a secondary amine and a non-competitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype. It is a white, odorless, or practically odorless, crystalline powder that is highly stable and soluble in water. Mecamylamine hydrochloride was previously used to treat hypertension but is now more commonly used in basic nicotine research and as an aid to smoking cessation.
Uses
Used in Neuroscience Research:
Mecamylamine hydrochloride is used as a non-selective nicotinic acetylcholine receptor blocker in aortic body neurons and in MLO-Y4 cells. It is also used as an additive in extracellular saline during current-clamp recordings to reduce synaptic input.
Used in Smoking Cessation:
Mecamylamine hydrochloride is used as an aid to smoking cessation due to its ability to block neuronal nicotinic acetylcholine receptors, reducing the rewarding effects of nicotine and potentially decreasing cravings for cigarettes.
Used in Neuropsychiatric Disorders:
Mecamylamine hydrochloride has been reported to be effective in various nicotine-responsive neuropsychiatric disorders, although further research is needed to fully understand its potential applications in this area.
Used in Drug Delivery:
Mecamylamine hydrochloride is supplied as tablets for oral use, each containing 2.5 mg of the active ingredient. The tablets also contain inactive ingredients such as calcium phosphate, D&C Yellow 10, FD&C Yellow 6, lactose, magnesium stearate, cornstarch, and talc.
Used in Chemical Synthesis:
Mecamylamine hydrochloride's chemical properties, such as its stability and solubility in water, make it a potentially useful compound in the synthesis of other pharmaceuticals or chemical products.
Therapeutic Function
Antihypertensive
Biological Activity
Non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.
Biochem/physiol Actions
Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier.
Metabolism
Mecamylamine hydrochloride (Inversine) is a secondary
amine and can therefore easily penetrate cell membranes.
Its absorption from the gastrointestinal tract is more complete
than that of the quaternary ammonium compounds.
Mecamylamine is well absorbed orally and crosses both
the blood-brain and placental barriers; its distribution is
not confined to the extracellular space. High concentrations
of the drug accumulate in the liver and kidney, and
it is excreted unchanged by the kidney. In contrast to most
of the highly ionized ganglionic blocking agents, mecamylamine
can produce central nervous system effects, including
tremors, mental confusion, seizures, mania, and
depression.The mechanism by which these central effects
are produced is unclear.Mecamylamine is rarely used today
as an antihypertensive drug because it blocks both
parasympathetic and sympathetic ganglia.
Check Digit Verification of cas no
The CAS Registry Mumber 826-39-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,2 and 6 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 826-39:
(5*8)+(4*2)+(3*6)+(2*3)+(1*9)=81
81 % 10 = 1
So 826-39-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H
