82801-73-8 Usage
Description
ARG-LYS-ARG-ALA-ARG-LYS-GLU is a synthetic peptide that acts as a specific cGMP-dependent protein kinase G (PKG) inhibitor. It is a nonphosphorylatable analog of a substrate corresponding to the serine-32 phosphorylation site in histone H2B. This peptide has been reported to block cGMP-dependent NMDA potentiation and nitric oxide-induced depression of GABA currents in cultured retinal amacrine cells.
Uses
Used in Pharmaceutical Industry:
ARG-LYS-ARG-ALA-ARG-LYS-GLU is used as a reversible substrate competitive inhibitor for protein kinase G. Its ability to inhibit PKG makes it a valuable tool in studying the role of this enzyme in various biological processes and potential therapeutic applications.
Used in Research Applications:
In research settings, ARG-LYS-ARG-ALA-ARG-LYS-GLU is used to investigate the effects of PKG inhibition on cellular signaling pathways, neurotransmission, and other physiological processes. This can help scientists better understand the mechanisms underlying various diseases and develop targeted therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 82801-73-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,8,0 and 1 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 82801-73:
(7*8)+(6*2)+(5*8)+(4*0)+(3*1)+(2*7)+(1*3)=128
128 % 10 = 8
So 82801-73-8 is a valid CAS Registry Number.
InChI:InChI=1/C38H74N18O10/c1-21(29(59)52-26(13-8-20-50-38(46)47)33(63)54-24(11-3-5-17-40)34(64)56-27(35(65)66)14-15-28(57)58)51-31(61)25(12-7-19-49-37(44)45)55-32(62)23(10-2-4-16-39)53-30(60)22(41)9-6-18-48-36(42)43/h21-27H,2-20,39-41H2,1H3,(H,51,61)(H,52,59)(H,53,60)(H,54,63)(H,55,62)(H,56,64)(H,57,58)(H,65,66)(H4,42,43,48)(H4,44,45,49)(H4,46,47,50)/t21-,22-,23-,24-,25-,26-,27-/m0/s1
