82909-47-5

Basic information

• Product Name: Myristic Acid Alkyne
• Synonyms: Myristic Acid Alkyne;tetradec-13-ynoic acid;13-Tetradecynoic Acid;Alkynyl Myristic Acid
• CAS NO: 82909-47-5
• Molecular Formula: C₁₄H₂₄O₂
• Molecular Weight: 224.33916
• Mol File: 82909-47-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 59.1°C (estimate)
• Boiling Point: 384.08°C (rough estimate)
• Appearance: /
• Density: 0.9192 (rough estimate)
• Refractive Index: 1.4154 (estimate)
• Storage Temp.: 2-8°C
• PKA: 4.78±0.10(Predicted)
• CAS DataBase Reference: Myristic Acid Alkyne(CAS DataBase Reference)
• NIST Chemistry Reference: Myristic Acid Alkyne(82909-47-5)
• EPA Substance Registry System: Myristic Acid Alkyne(82909-47-5)

Safety Data

• Hazardous Substances Data: 82909-47-5(Hazardous Substances Data)

Usage

Description

Myristic Acid Alkyne, also known as Alkynyl Myristic Acid, is a chemical compound that features an alkynyl group attached to a myristic acid backbone. It is utilized in biochemical research and has unique properties that allow for the identification and characterization of post-translationally modified proteins through a process known as Click Chemistry.

Uses

Used in Biochemical Research:
Myristic Acid Alkyne is used as a biochemical tool for the detection and analysis of myristoylated proteins. It aids researchers in understanding the role of myristoylation, a post-translational modification, in protein function and regulation.
Used in Click Chemistry:
Myristic Acid Alkyne is employed as a reagent in Click Chemistry, a set of bioorthogonal reactions that allow for the selective modification of biomolecules in living systems. This technique is valuable for studying protein interactions, tracking proteins within cells, and developing new drug delivery systems.
Used in Drug Development:
In the pharmaceutical industry, Myristic Acid Alkyne can be used as a starting material or a component in the synthesis of new drugs targeting proteins involved in diseases. Its ability to selectively modify and track myristoylated proteins can lead to the development of more effective and targeted therapies.
Used in Diagnostics:
Myristic Acid Alkyne can be utilized in the development of diagnostic tools that rely on the detection of specific protein modifications. Its application in Click Chemistry allows for the creation of灵敏的 and specific assays to monitor disease progression or therapeutic efficacy.
Overall, Myristic Acid Alkyne is a versatile compound with applications in various scientific and medical fields, primarily due to its role in the study and manipulation of myristoylated proteins.

Upstream product

• 7331-03-5 13-tetradecenoic acid 
• 73367-80-3 12-bromododecanoic acid 
• 1216963-74-4 lithium acetylide-ethylenediamine complex 
• 55182-92-8 9-tetradecynoic acid 
• 55182-96-2 11-tetradecynoic acid 
• 18202-12-5 14-hydroxy-1-tetradecyne 
• 26186-02-7 tridec-1-yne 
• 51309-22-9 tetradec-2-yn-1-ol 
• 3344-77-2 12-bromododecanol 
• 55182-74-6 1-hydroxy-tetradec-3-yne 
• 16339-75-6 12-tridecenyl alcohol 
• 16339-76-7 13-Bromo-1-tridecene 

Downstream Products

• 149221-81-8 1,2-di-O-(13-tetradecyn-1-ol)-3-benzyl-sn-glycerol 
• 139100-94-0 2-palmitoyl-3-(4-methoxybenzyl)-sn-glycerol 
• 139100-85-9 1,2-di-13-tetradecyn-1-oyl-3-(4-methoxybenzyl)-sn-glycerol 
• 149221-84-1 1,2-O-(13,15-octacosadiyne-1,28-dioyl)-3-benzyl-sn-glycerol 
• 1042435-58-4 C₁₀₂H₁₆₃N₂₅O₂₁ 
• 1001588-16-4 C₂₂H₂₈O₂ 
• 1001588-22-2 C₂₄H₂₈O₂ 
• 1001588-30-2 C₂₆H₂₈O₂ 
• 139100-88-2 1,2-(13,15-octacosadiyne-1,28-dioyl)-3-(4-methoxybenzyl)-sn-glycerol 
• 56909-03-6 methyl 13-tetradecynoate 

Relevant articles and documents

INSULIN CONJUGATES

The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Robust fluorescent detection of protein fatty-acylation with chemical reporters

Fatty-acylation of proteins in eukaryotes is associated with many fundamental cellular processes but has been challenging to study due to limited tools for rapid and robust detection of protein fatty-acylation in cells. The development of azido-fatty acid

Synthesis of carboxyl-tethered symmetric conjugated polyenes as fluorescent transmembrane probes of lipid bilayers

The synthesis of a new series of fluorescent transmembrane probes in which two hydrophilic methyl ester or carboxyl groups are connected by a polymethylene chain, with four, five or six conjugated double bonds in a central position, is reported. The length of the linear structures was designed to match the width of typical lipid bilayers. These bolaamphiphilic compounds result, with overall yields higher than 80%, from an easy PdII-catalyzed double cross-coupling between terminal acetylene esters and conjugated 1,ω-dihalopolyenes, followed by selective triple bond partial reduction with activated zinc, and iodine isomerization to the all-(E) isomer. An alternative approach, based on a Stille double cross-coupling between the appropriate all-(E)-ω-halopolyenes and (E)-bis(tributylstannyl)ethene, yielded mixtures that could not be resolved by standard chromatographic methods due to the presence of other simultaneous coupling reactions, which are also discussed in detail. Nevertheless, the Stille method can be of utility for the obtention of carbonyl-polyene conjugated analogs. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.