83-49-8 Usage
Description
Hyodeoxycholic acid is a naturally occurring secondary bile acid that is produced by the gut flora in the small intestine. It is obtained from chenodeoxycholic acid during enterohepatic circulation of bile in rats. As a member of the class of 5beta-cholanic acids, it is characterized by its (5beta)-cholan-24-oic acid structure, substituted by alpha-hydroxy groups at positions 3 and 6. Hyodeoxycholic acid is a white solid and has potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
Hyodeoxycholic acid is used as an antitumor agent for its potential anticancer properties. It is a potential bile acid metabolite that can be used in the development of drugs targeting cancer cells.
Used in Research Applications:
Hyodeoxycholic acid is used as a labeled compound in research settings to study its properties and effects on biological systems. The unlabeled version of hyodeoxycholic acid is isolated from pig bile, providing a natural source for research purposes.
Used in Drug Development:
Hyodeoxycholic acid is used as a key component in the development of new drugs and therapies. Its isolation from pig bile and its role as a bile acid metabolite make it a valuable resource for drug discovery and development.
Purification Methods
Crystallise -hyodeoxycholic acid from EtOAc or Me2CO. The K salt separates in needles from an alcoholic solution of the acid when an equivalent of KOMe is added (see lithocholic acid). [Weiland & Gumlish Hoppe Seyler's Z Physiol Chem 215 18 1933, Windaus & Bohne Justus Liebigs Ann Chem 433 278 1923, Beilstein 10 III 1631.]
Check Digit Verification of cas no
The CAS Registry Mumber 83-49-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 3 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 83-49:
(4*8)+(3*3)+(2*4)+(1*9)=58
58 % 10 = 8
So 83-49-8 is a valid CAS Registry Number.
InChI:InChI=1/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1
83-49-8Relevant articles and documents
PROCESS FOR THE PREPARATION OF CHOLANIC ACIDS
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Page/Page column 2, (2008/06/13)
A process for the preparation of high purity cholanic acids, typically in purity equal to or higher than 99%.
Xanthomonas maltophilia CBS 897.97 as a source of new 7β- and 7α-hydroxysteroid dehydrogenases and cholylglycine hydrolase: Improved biotransformations of bile acids
Pedrini, Paola,Andreotti, Elisa,Guerrini, Alessandra,Dean, Mariangela,Fantin, Giancarlo,Giovannini, Pier Paolo
, p. 189 - 198 (2007/10/03)
The paper reports the partial purification and characterization of the 7β- and 7α-hydroxysteroid dehydrogenases (HSDH) and cholylglycine hydrolase (CGH), isolated from Xanthomonas maltophilia CBS 897.97. The activity of 7β-HSDH and 7α-HSDH in the reduction of the 7-keto bile acids is determined. The affinity of 7β-HSDH for bile acids is confirmed by the reduction, on analytical scale, to the corresponding 7β-OH derivatives. A crude mixture of 7α- and 7β-HSDH, in soluble or immobilized form, is employed in the synthesis, on preparative scale, of ursocholic and ursodeoxycholic acids starting from the corresponding 7α-derivatives. On the other hand, a partially purified 7β-HSDH in a double enzyme system, where the couple formate/formate dehydrogenase allows the cofactor recycle, affords 6α-fluoro-3α, 7β-dihydroxy-5β-cholan-24-oic acid (6-FUDCA) by reduction of the corresponding 7-keto derivative. This compound is not obtainable by microbiological route. The efficient and mild hydrolysis of glycinates and taurinates of bile acids with CGH is also reported. Very promising results are also obtained with bile acid containing raw materials.
Progesterone from 3-alpha-hydroxy-6-oxo-5-alpha-cholic acid
Lehmann,Tepper,Hilgetag
, p. 176 - 181 (2007/10/06)
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