83-93-2 Usage
Description
5,6-Dihydro-benzo[c]acridine-7-carboxylic acid is a chemical compound with a molecular formula C17H13NO2. It belongs to the class of benzo[c]acridine derivatives, which are known for their diverse biological and pharmacological activities. This organic compound may hold potential applications in medicinal chemistry and drug discovery due to its unique structure and properties. Further research is necessary to fully explore its potential uses and benefits across various applications.
Uses
Used in Medicinal Chemistry:
5,6-Dihydro-benzo[c]acridine-7-carboxylic acid is used as a chemical compound in medicinal chemistry for its potential to contribute to the development of new drugs. Its unique structure and properties may allow it to interact with biological targets in ways that could lead to the creation of novel therapeutic agents.
Used in Drug Discovery:
In the field of drug discovery, 5,6-Dihydro-benzo[c]acridine-7-carboxylic acid is used as a starting point for designing and synthesizing new pharmaceuticals. Its presence in the benzo[c]acridine class suggests it may possess bioactive properties that can be harnessed to treat various diseases and conditions.
Used in Pharmaceutical Research:
5,6-Dihydro-benzo[c]acridine-7-carboxylic acid is utilized in pharmaceutical research to investigate its potential as a lead compound for drug development. Researchers may explore its interactions with biological systems, its pharmacokinetics, and its efficacy in treating specific conditions to determine its suitability as a drug candidate.
Used in Chemical Synthesis:
5,6-DIHYDRO-BENZO[C]ACRIDINE-7-CARBOXYLIC ACID is also used in chemical synthesis processes to create derivative molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science. Its unique structure may enable the development of new compounds with improved properties or novel functions.
Check Digit Verification of cas no
The CAS Registry Mumber 83-93-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 3 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 83-93:
(4*8)+(3*3)+(2*9)+(1*3)=62
62 % 10 = 2
So 83-93-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H13NO2/c20-18(21)16-13-7-3-4-8-15(13)19-17-12-6-2-1-5-11(12)9-10-14(16)17/h1-8H,9-10H2,(H,20,21)
83-93-2Relevant articles and documents
Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework
Giardina, Giuseppe A. M.,Sarau, Henry M.,Farina, Carlo,Medhurst, Andrew D.,Grugni, Mario,Raveglia, Luca F.,Schmidt, Dulcie B.,Rigolio, Roberto,Luttmann, Mark,Vecchietti, Vittorio,Hay, Douglas W. P.
, p. 1794 - 1807 (2007/10/03)
A novel class of potent and selective non-peptide neurokinin-3 (NK-3) receptor antagonists, featuring the 4-quinolinecarboxamide framework, has been designed based upon chemically diverse NK-1 receptor antagonists. The novel compounds 33-76, prompted by chemical modifications of the prototype 4, have been characterized by binding analysis using a membrane preparation of chinese hamster ovary (CHO) cells expressing the human neurokinin-3 receptors (hNK-3-CHO), and clear structure-activity relationships (SARs) have been established. From SARs, (R)-N-[α-(methoxycarbonyl)benzyl]-2- phenylquinoline-4-carboxamide (65, SB 218795, hNK-3-CHO binding K(i) = 13 nM) emerged as one of the most potent compounds of this novel class. Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding K(i) = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding K(i) = >100 μM). In vitro functional studies in rabbit isolated iris sphincter muscle preparation demonstrated that 65 is a competitive antagonist of the contractile response induced by the potent and selective NK-3 receptor agonist senktide with a K(b) = 43 nM. Overall, the data indicate that 65 is a potent and selective hNK-3 receptor antagonist and a useful lead for further chemical optimization.
