830-02-4

Basic information

• Product Name: 2-fluoro-3-(4-methoxyphenyl)-2-propen-1-ol
• Synonyms: 2-fluoro-3-(4-methoxyphenyl)-2-propen-1-ol
• CAS NO: 830-02-4
• Molecular Weight: 182.195
• Mol File: 830-02-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-fluoro-3-(4-methoxyphenyl)-2-propen-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-3-(4-methoxyphenyl)-2-propen-1-ol(830-02-4)
• EPA Substance Registry System: 2-fluoro-3-(4-methoxyphenyl)-2-propen-1-ol(830-02-4)

Safety Data

• Hazardous Substances Data: 830-02-4(Hazardous Substances Data)

Upstream product

• 113128-33-9 Methyl 2-fluoro-3-(4-methoxyphenyl)prop-2-enoate 
• 1608-24-8 3-(2,2-difluoroethenyl)anisole 
• 123-11-5 4-methoxy-benzaldehyde 
• 836-29-3 2-fluoro-3-(4-methoxyphenyl)acrylic acid ethyl ester 
• 194800-71-0 (Z)-2-fluoro-3-(4-methoxyphenyl)acrylaldehyde 
• 1963-36-6 4-methoxycinnamaldehyde 
• 26927-88-8 (Z)-3-(4-methoxyphenyl)-2-fluoroacrylic acid ethyl ester 
• 26927-87-7 (E)-ethyl 2-fluoro-3-(4-methoxyphenyl)-2-propenoate 

Downstream Products

• 1221508-36-6 (S)-2-fluoro-3-(4-methoxyphenyl)propan-1-ol 
• 1112130-83-2 (S)-N-[(E,2Z)-2-fluoro-3-(4-methoxyphenyl)-2-propenylidene]-2-methyl-2-propanesulfinamide 
• 1112131-02-8 N-[(Z)-2-fluoro-3-(4-methoxyphenyl)-1-phenyl-2-propenyl]-2-methyl-2-propanesulfinamide 
• 1112130-99-0 N-[(Z)-2-fluoro-3-(4-methoxyphenyl)-1-phenyl-2-propenyl]-2-methyl-2-propanesulfinamide 
• 1112131-14-2 N-[(Z)-2-fluoro-1-isopropyl-3-(4-methoxyphenyl)-2-propenyl]-2-methyl-2-propanesulfinamide 
• 1112131-10-8 N-[(Z)-2-fluoro-1-isopropyl-3-(4-methoxyphenyl)-2-propenyl]-2-methyl-2-propanesulfinamide 
• 1112131-17-5 N-[(Z)-2-fluoro-1-isobutyl-3-(4-methoxyphenyl)-2-propenyl]-2-methyl-2-propanesulfinamide 
• 1112131-20-0 N-[(Z)-1-benzyl-2-fluoro-3-(4-methoxyphenyl)-2-propenyl]-2-methyl-2-propanesulfinamide 
• 1112131-23-3 N-(1-[(Z)-1-fluoro-2-(4-methoxyphenyl)ethenyl]-3-butenyl)-2-methyl-2-propanesulfinamide 
• 1112131-26-6 N-[(Z)-2-fluoro-3-(4-methoxyphenyl)-1-vinyl-2-propenyl]-2-methyl-2-propanesulfinamide 
• 194800-71-0 (Z)-2-fluoro-3-(4-methoxyphenyl)acrylaldehyde 
• 5406-18-8 3-(p-methoxyphenyl)-1-propanol 

Relevant articles and documents

Copper-Catalyzed Stereoselective Defluorinative Borylation and Silylation of gem-Difluoroalkenes

The copper-catalyzed stereoselective defluorinative borylation and silylation of gem-difluoroalkenes was developed. The protocol led to the exclusive formation of Z type monofluoroalkenyl borons and silanes in generally good efficiency with broad substrat

One-Pot l-Proline-Mediated Stereoselective α-C(sp2)–H Fluorination of α,β-Unsaturated Aldehydes through Methoxyfluorination–Elimination

A one-pot, two-step l-proline-mediated stereoselective α-C(sp2)–H fluorination of α,β-unsaturated aldehydes towards their corresponding (Z)-α-fluoro-α,β-unsaturated aldehydes has been developed. The first step utilises Selectfluor as a fluorinating agent in CH3NO2/MeOH forming (Z)-α-fluoro-α,β-unsaturated aldehydes and their corresponding dimethyl acetals through methoxyfluorination-elimination. In the second step, water is added to promote the hydrolytic cleavage of the dimethyl acetals. The obtained (Z)-α-fluoro-α,β-unsaturated aldehydes were smoothly reduced to the corresponding alcohols by using NaBH4.

Highly regioselective SN2′ reaction of β-fluoroallylic phosphates with organocopper reagents and its application to the synthesis of fluorine-containing carbocycles

Treatment of β-fluoroallyl phosphates with 2.2 equiv. of organocuprates, prepared readily from 2.2 equiv. each of CuCN and organometallics (organolithium reagents, Grignard reagents, and organozinc reagents), in THF at -40 to 0 °C for 0.25 to 24 h gave γ-products in a highly regioselective manner. Thus obtained γ-adducts were subjected to the ring-closing metathesis, the corresponding cyclic fluoroalkenes being afforded in good yields.