831217-43-7 Usage
Description
1(2H)-PyriMidinehexanoic acid, 4-[1,1'-biphenyl]-4-yl-3,4-dihydro-6-Methyl-2-oxo-5-[(phenylMethoxy)carbonyl]is a complex organic compound with a unique chemical structure. It is characterized by a pyrimidinehexanoic acid core, a biphenyl group, a methyl group, and a phenylmethoxycarbonyl moiety. 1(2H)-PyriMidinehexanoic acid, 4-[1,1'-biphenyl]-4-yl-3,4-dihydro-6-Methyl-2-oxo-5-[(phenylMethoxy)carbonyl]has potential applications in various fields due to its specific chemical properties and interactions.
Uses
Used in Pharmaceutical Research:
1(2H)-PyriMidinehexanoic acid, 4-[1,1'-biphenyl]-4-yl-3,4-dihydro-6-Methyl-2-oxo-5-[(phenylMethoxy)carbonyl]is used as an inhibitor of heat shock protein 70 (Hsp70) co-chaperone HDJ2 (human Ydj1/DNAJA1) for studying the influence of HDJ2 on the regulation of ribonucleotide reductase (RNR) activity in HEK293 cells. This application helps researchers understand the role of HDJ2 in cellular processes and its potential as a therapeutic target.
Used in Cellular Biology Studies:
1(2H)-PyriMidinehexanoic acid, 4-[1,1'-biphenyl]-4-yl-3,4-dihydro-6-Methyl-2-oxo-5-[(phenylMethoxy)carbonyl]is also used as an Hsp70 inhibitor to study the effect of Hsp70 chaperone on b5‐ops glycosylation in the side populations (SP) HeLa cells. By inhibiting Hsp70, researchers can investigate the role of this chaperone protein in cellular processes and its potential involvement in various diseases.
Biochem/physiol Actions
116-9e is a dihhydropyrimidine compound.
Check Digit Verification of cas no
The CAS Registry Mumber 831217-43-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,3,1,2,1 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 831217-43:
(8*8)+(7*3)+(6*1)+(5*2)+(4*1)+(3*7)+(2*4)+(1*3)=137
137 % 10 = 7
So 831217-43-7 is a valid CAS Registry Number.
831217-43-7Relevant articles and documents
Synthesis and structure-activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target
Ireland, Alex W.,Gobillot, Theodore A.,Gupta, Tushar,Seguin, Sandlin P.,Liang, Mary,Resnick, Lynn,Goldberg, Margot T.,Manos-Turvey, Alexandra,Pipas, James M.,Wipf, Peter,Brodsky, Jeffrey L.
, p. 6490 - 6502 (2014)
Polyomavirus infections are common and relatively benign in the general human population but can become pathogenic in immunosuppressed patients. Because most treatments for polyomavirus-associated diseases nonspecifically target DNA replication, existing
Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation
Wright, Christine M.,Chovatiya, Raj J.,Jameson, Nora E.,Turner, David M.,Zhu, Guangyu,Werner, Stefan,Huryn, Donna M.,Pipas, James M.,Day, Billy W.,Wipf, Peter,Brodsky, Jeffrey L.
, p. 3291 - 3301 (2008/09/19)
The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-
