83540-94-7 Usage
Description
(R)-2-Hydroxysuccinic Acid Methyl Ester, also known as (R)-Methyl 2-hydroxysuccinate, is a chiral organic compound with the molecular formula C5H8O5. It is a methyl ester derivative of (R)-2-hydroxysuccinic acid, featuring a hydroxyl group and a methyl ester group attached to a succinic acid backbone. (R)-2-Hydroxysuccinic Acid Methyl Ester exhibits a specific stereochemistry, with the R-configuration at the chiral center, which is crucial for its biological activity and potential applications.
Uses
Used in Pharmaceutical Industry:
(R)-2-Hydroxysuccinic Acid Methyl Ester is used as an intermediate in the synthesis of pharmaceutical compounds for the treatment of various diseases, such as cancer and amyloidosis. Its unique stereochemistry and functional groups make it a valuable building block in the development of novel therapeutic agents.
Used in Cancer Treatment:
(R)-2-Hydroxysuccinic Acid Methyl Ester is used as a key component in the preparation of drugs that target cancer cells. Its incorporation into pharmaceutical compounds can enhance their selectivity and efficacy in treating different types of cancer, potentially leading to improved patient outcomes.
Used in Amyloidosis Treatment:
(R)-2-Hydroxysuccinic Acid Methyl Ester is also used in the development of therapeutic agents for the treatment of amyloidosis, a group of rare diseases characterized by the abnormal accumulation of protein deposits in tissues and organs. Its potential to modulate protein aggregation and clearance pathways makes it a promising candidate for the development of new treatments for these debilitating conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 83540-94-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,5,4 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 83540-94:
(7*8)+(6*3)+(5*5)+(4*4)+(3*0)+(2*9)+(1*4)=137
137 % 10 = 7
So 83540-94-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H8O5/c1-10-5(9)3(6)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)/t3-/m1/s1
83540-94-7Relevant articles and documents
Structural and Functional Analysis of Bacterial Sulfonosphingolipids and Rosette-Inducing Factor 2 (RIF-2) by Mass Spectrometry-Guided Isolation and Total Synthesis
Beemelmanns, Christine,Jautzus, Theresa,King, Nicole,Leichnitz, Daniel,Peng, Chia-Chi,Ragu?, Luka,Regestein, Lars,Rutaganira, Florentine U. N.
supporting information, (2022/01/04)
We have analyzed the abundance of bacterial sulfonosphingolipids, including rosette-inducing factors (RIFs), in seven bacterial prey strains by using high-resolution tandem mass spectrometry (HRMS2) and molecular networking (MN) within the Glob
ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
-
Paragraph 274; 278; 279, (2016/09/26)
The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans a
Direct, catalytic synthesis of carbapenams via cycloaddition/rearrangement cascade reaction: Unexpected acetylenes' structure effect
Mames, Adam,Stecko, Sebastian,Mikolajczyk, Paulina,Soluch, Magdalena,Furman, Bartlomiej,Chmielewski, Marek
supporting information; experimental part, p. 7580 - 7587 (2011/03/17)
Reactions of acetylenes derived from glyceraldehyde and propargyl aldehyde show remarkable reactivity in Kinugasa cycloaddition/rearrangement cascade process catalyzed by Cu(I) ion. Reactions proceed by formation of a rigid dinuclear copper(I) complex in which each copper ion is coordinated to one or both oxygen atoms in the acetylene molecule and to both triple bonds. It has been demonstrated that one oxygen atom can be replaced by the phenyl ring, which is able to coordinate the copper ion by the aromatic sextet. Kinugasa reactions that proceed in a high yield can also be performed in the presence of a catalytic amount of the copper salt to provide products in an acceptable yield without a decrease of diastereoselectivity.