836-07-7Relevant articles and documents
Method for preparing 2-iodo aryl ether under action of alkali metal hydride
-
Paragraph 0028, (2021/06/22)
The invention discloses a method for preparing 2-iodo aryl ether under the action of alkali metal hydride, which comprises the following steps: adding alkali metal hydride and phenol into a solvent, then adding 1, 2-diiodo aromatic hydrocarbon, and reacti
Intramolecular Aryl Migration of Diaryliodonium Salts: Access to ortho-Iodo Diaryl Ethers
Chen, Huangguan,Han, Jianwei,Wang, Limin
, p. 12313 - 12317 (2018/09/10)
By using vicinal trifluoromethanesulfonate-substituted diaryliodonium salts, a novel approach was developed for the synthesis of ortho-iodo diaryl ethers by intramolecular aryl migration. The reaction conditions are mild with a broad substrate scope. Mechanistic insight suggests a sulfonyl-directed nucleophilic aromatic substitution pathway. Additionally, the product ortho-iodo diaryl ethers serve as versatile synthons as demonstrated with several coupling reactions. Furthermore, a useful thyroxine analogue of the 3-iodo-l-thyronine (3-T1) derivative was synthesized by this aryl migration procedure.
Copper-mediated N- and O-arylations with arylboronic acids in a continuous flow microreactor: a new avenue for efficient scalability
Singh, Brajendra K.,Stevens, Christian V.,Acke, Davy R.J.,Parmar, Virinder S.,Van der Eycken, Erik V.
scheme or table, p. 15 - 18 (2009/04/10)
A continuous flow procedure has been elaborated for the copper(II)-mediated N- and O-arylation of a range of compounds with arylboronic acids using a commercial microreactor setup. The compounds could be continuously generated in good yields paving the way for efficient scalability.