837-81-0

Basic information

• Product Name: 1-<2-Fluor-phenyl>-3-phenyl-1-hydroxy-propan
• Synonyms: 1-<2-Fluor-phenyl>-3-phenyl-1-hydroxy-propan
• CAS NO: 837-81-0
• Molecular Weight: 230.282
• Mol File: 837-81-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-<2-Fluor-phenyl>-3-phenyl-1-hydroxy-propan(CAS DataBase Reference)
• NIST Chemistry Reference: 1-<2-Fluor-phenyl>-3-phenyl-1-hydroxy-propan(837-81-0)
• EPA Substance Registry System: 1-<2-Fluor-phenyl>-3-phenyl-1-hydroxy-propan(837-81-0)

Safety Data

• Hazardous Substances Data: 837-81-0(Hazardous Substances Data)

Upstream product

• 445-26-1 1-(2-fluorophenyl)ethanol 
• 100-51-6 benzyl alcohol 
• 446-52-6 2-Fluorobenzaldehyde 

Relevant articles and documents

Room-Temperature Guerbet Reaction with Unprecedented Catalytic Efficiency and Enantioselectivity

We report herein an unprecedented highly efficient Guerbet-type reaction at room temperature (catalytic TON up to >6000). This β-alkylation of secondary methyl carbinols with primary alcohols has significant advantage of delivering higher-order secondary alcohols in an economical, redox-neutral fashion. In addition, the first enantioselective Guerbet reaction has also been achieved using a commercially available chiral ruthenium complex to deliver secondary alcohols with moderate yield and up to 92 % ee. In both reactions, the use of a traceless ketone promoter proved to be beneficial for the catalytic efficiency.