83808-19-9

Basic information

• Product Name: (S)-4-broMo-2,3-dihydro-1H-inden-1-ol
• Synonyms: (S)-4-broMo-2,3-dihydro-1H-inden-1-ol;(1S)-4-bromo-2,3-dihydro-1H-inden-1-ol;(1R)-4-BROMO-2,3-DIHYDRO-1H-INDEN-1-OL(WX142569)
• CAS NO: 83808-19-9
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.07116
• Mol File: 83808-19-9.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (S)-4-broMo-2,3-dihydro-1H-inden-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-broMo-2,3-dihydro-1H-inden-1-ol(83808-19-9)
• EPA Substance Registry System: (S)-4-broMo-2,3-dihydro-1H-inden-1-ol(83808-19-9)

Safety Data

• Hazardous Substances Data: 83808-19-9(Hazardous Substances Data)

Usage

Description

(S)-4-Bromo-2,3-dihydro-1H-inden-1-ol, with the molecular formula C9H9BrO, is a chiral chemical compound featuring two non-superimposable mirror images known as enantiomers. (S)-4-broMo-2,3-dihydro-1H-inden-1-ol is characterized by its unique chemical structure, which includes a bromine atom and a hydroxyl group attached to a bicyclic ring system. This structure endows it with distinctive reactivity and the potential for selective transformations in a range of chemical reactions.

Uses

Used in Organic Synthesis:
(S)-4-broMo-2,3-dihydro-1H-inden-1-ol is utilized as a fundamental building block in organic synthesis, playing a crucial role in the creation of more complex molecules. Its unique structure and reactivity make it a valuable component in the development of advanced chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, (S)-4-broMo-2,3-dihydro-1H-inden-1-ol is employed for its potential applications in drug discovery and development. Its distinctive chemical properties allow for the design and synthesis of novel therapeutic agents with specific biological activities.
Used in Agrochemical Industry:
The agrochemical industry also benefits from the use of (S)-4-broMo-2,3-dihydro-1H-inden-1-ol, where it serves as a key intermediate in the synthesis of various agrochemical products. Its unique structural features contribute to the development of innovative and effective solutions for agricultural applications.

Upstream product

• 15115-60-3 4-bromo-2,3-dihydroinden-1-one 
• 16657-10-6 (±)-4-bromo-2,3-dihydro-1H-inden-1-ol 

Downstream Products

• 1202578-07-1 (3S)-3-(4-{[(1R)-4-(Difluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol 
• 1202576-60-0 (3S)-3-(4-{[(1R)-4-(difluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid 
• 1380388-76-0 (S)-4-(2,6-dimethyl-phenyl)-indan-1-ol 
• 1404230-16-5 (S)-4-phenoxy-2,3-dihydro-1H-inden-1-ol 
• 1372195-58-8 4-(((1S)-1-((tetrahydro-2H-pyran-2-yl)oxy)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile 
• 1372195-60-2 (S)-4-((1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile 
• 1312789-14-2 4-((1R)-4-bromo-2,3-dihydro-1H-inden-1-yloxy)phenylboronic acid N-methyliminodiacetic acid ester 
• 1372195-80-6 methyl 4-(N,N-bis(2-(trimethylsilyl)ethoxymethyl)sulfamoyl)-3-(4-(((R)-4-(4-cyanophenoxy)-2,3-dihydro-1H-inden-1-yl)oxy)phenyl)butanoate 
• 1372192-35-2 4-(((1R)-1-(4-(1,1-dioxo-3-oxo-1,2-thiazinan-5-yl)phenoxy)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile 
• 1458652-60-2 methyl 2-((3S)-6-((1R)-4-(2,6-dimethyl-4-((tetrahydrofuran-3-yl)methoxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate 

Relevant articles and documents

Ru-catalyzed mechanochemical asymmetric transfer hydrogenations in aqueous media using chitosan as chirality source

As the demand for sustainable methods increases, synthetic chemistry is focusing on the application of environmentally benign methods, such as fast reactions induced by alternative energy transmission. Chitosan is a chiral biopolymer of natural origin, which can be used in asymmetric catalysis. The application of Ru-chitosan complexes along with the mechanochemical activation may open great opportunities for sustainable preparation of optically pure alcohols. In the present study, we optimized the mechanochemical asymmetric transfer hydrogenation of 4-chromanone, carried out in a mixing mill. The reaction was catalyzed by the in situ formed Ru-chitosan complex, applying HCOONa as the hydrogen donor in aqueous media. We examined the mechanical effects of different grinding media sizes, then explored the scope of the system using 24 prochiral ketones, which ranged from hetero- and carbocyclic ketones to acetophenone derivatives. In most of the cases, the reactions were successfully scaled up to 1 mmol and the products were isolated in good yields and outstanding enantioselectivities. Our present study is a significant step forward to the development of environmentally benign and sustainable enantioselective processes, as the alternative activation method provided optically enriched alcohols using a biodegradable chirality source in aqueous media.

Asymmetric Magnesium-Catalyzed Hydroboration by Metal-Ligand Cooperative Catalysis

Asymmetric catalysis with readily available, cheap, and non-toxic alkaline earth metal catalysts represents a sustainable alternative to conventional synthesis methodologies. In this context, we describe the development of a first MgII-catalyzed enantioselective hydroboration providing the products with excellent yields and enantioselectivities. NMR spectroscopy studies and DFT calculations provide insights into the reaction mechanism and the origin of the enantioselectivity which can be explained by a metal-ligand cooperative catalysis pathway involving a non-innocent ligand.

Novel phenyl propionic acid compound as GPR40 agonist

The present invention relates to a novel phenyl propionic acid derivative having the structure of chemical formula (I) and having a GPR40 agonist action that shows an inhibitory effect on the elevation of blood glucose level through promoting insulin secretion according to glucose tolerance; a preparation method of the same; and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating metabolic diseases. In the chemical formula (I), groups of R_1-R_4, and X are as defined in claim 1.COPYRIGHT KIPO 2018