83999-28-4Relevant articles and documents
Gewald synthesis, antitumor profile and molecular modeling of novel 5-acetyl-4-((4-acetylphenyl)amino)-2-aminothiophene-3-carbonitrile scaffolds
Algothami, Wesam M.,Khalifa, Mohamed E.
, (2020)
Novel targets of 2-aminothiophene derivatives (2–9) were synthesized based upon preparation of the newly 5-acetyl-4-((4-acetylphenyl)amino)-2-aminothiophene-3-carbonitrile (2) using Gewald methodology. Several functional chemical reactions were performed
Synthesis of β-Ketoamide Curcumin Analogs for Anti-Diabetic and AGEs Inhibitory Activities
Banuppriya, Govindharasu,Sribalan, Rajendran,Fathima, Sulthan Alavudeen Rizwan,Padmini, Vediappen
, (2018/08/03)
Two different series of novel β-ketoamide curcumin analogs enriched in biological activities have been synthesized. The synthesized compounds were screened for their in?vitro anti-diabetic and AGEs inhibitory activities and exhibited potent to good anti-diabetic and AGEs inhibitory activities. The molecular docking study was also performed with the α-amylase enzyme.