84138-86-3

Basic information

• Product Name: N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE
• Synonyms: N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE;N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxyadenosine;N6-Benzoyl-5'-O-(4,4-dimethoxytrityl)-3'-deoxy adenosine;N6-Benzoyl-3'-deoxy-5'-O-DMT-adenosine
• CAS NO: 84138-86-3
• Molecular Formula: C₃₈H₃₅N₅O₆
• Molecular Weight: 657.71
• Mol File: 84138-86-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE(CAS DataBase Reference)
• NIST Chemistry Reference: N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE(84138-86-3)
• EPA Substance Registry System: N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE(84138-86-3)

Safety Data

• Hazardous Substances Data: 84138-86-3(Hazardous Substances Data)

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 73-03-0 cordycepin 
• 98-88-4 benzoyl chloride 
• 4395-38-4 N₆,2',5'-tribenzoyl-3'-deoxyadenosine 
• 207347-40-8 Acetic acid (2R,3R,5S)-2-(6-benzoylamino-purin-9-yl)-5-((R)-1,2-diacetoxy-ethyl)-tetrahydro-furan-3-yl ester 
• 207347-41-9 N-{9-[(2R,3R,5S)-5-((R)-1,2-Dihydroxy-ethyl)-3-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 86234-44-8 (2R,3R,5S)-2-(6-Amino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol 
• 76902-49-3 N-(9-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 

Downstream Products

• 207347-42-0 N⁶-benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 2'-(2-cyanoethyl diisopropylphosphoramidite) 
• 138800-30-3 N⁶,O^2'-dibenzoyl-5'-(dimethoxytrityl)-3'-deoxyadenosine 
• 138824-83-6 Benzoic acid (2R,3R,5S)-5-[[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-(2-cyano-ethoxy)-phosphanyloxymethyl]-2-(6-benzoylamino-purin-9-yl)-tetrahydro-furan-3-yl ester 
• 128893-74-3 N⁶,O^2'-dibenzoyl-3'-deoxyadenosine 
• 486424-66-2 N⁶-benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-adenylic acid 2-{[6-(benzoylamino)-9H-purin-9-yl]methoxy}ethyl 2-cyanoethyl ester 

Relevant articles and documents

CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS

A class of polycyclic compounds of general formula (II), of general formula (II'), or of general formula (II"), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xsu

Inhibition of HIV-1 Replication by Chemically Synthesized, Nuclease-Resistant, Nontoxic (2'->5')-Oligoadenylate Agonists

The chemical syntheses of nuclease-resistant, nontoxic bioactive (2'-5')agonists, 3'-deoxyadenylyl-(2'->5')-3'-deoxyadenylyl-(2'->5')-3'-deoxyadenylyl-(2'->2")-9-[(2"-hydroxyethoxy)methyl]adenine (d3A-d3A-d3A-etherA; 36), 1-benzyl-3'-deoxyadenylyl-(2'->5')-3'-deoxyadenylyl-(2'->5')-3'-deoxyadenylyl-(2'->2")-9-[2"-hydroxyethoxy)methyl]adenine (N1-benzyl-d3A-d3A-d3A-etherA; 37), N6-benzyl-3'-deoxyadenylyl-(2'->5')-3'-deoxyadenylyl-(2'->5')-3'-deoxyadenylyl-(2'->2")-9-[(2"-hydroxyethoxy)methyl]adenine (N6-benzyl-d3A-d3A-d3A-etherA; 38), N6-benzyladenylyl-(2'->5')-adenylyl-(2'->5')-adenylyl-(2'->2")-9-[(2"-hydroxyethoxy)methyl]adenine (N6-benzyl-A-A-A-etheA; 39), as well as the biological activities of 37, 38, and already synthesized and published adenylyl-(2'->5')-adenylyl-(2'->5')-adenylyl-(2'->2")-9-[(2"-hydroxyethoxy)methyl]adenine (A-A-A-etherA; 40), are described. The above (2'-5')A derivatives 37-40 inhibit HIV-1 replication as measured by inhibition of syncytia formation, HIV-1 reverse transcriptase activity, or HIV-1 p24-antigen expression, with no evidence of cytotoxicity. Oligonucleotides 37, 38, and 40 were taken up intact into T cells in culture of cytoplasmic concentrations sufficient to activate the latent endoribonuclease, RNase L. N6-Benzyl-d3A-d3A-d3A-etherA (38) also exerts immunostimulatory effects by increasing expression of monocyte chemotactic protein-1 (MCP-1), and thereby, competing with HIV-1 for binding to a critical HIV-coreceptor.

O-Alkyl-5',5'-dinucleoside phosphates as prodrugs of 3'-azidothymidine and cordycepin

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