84194-36-5Relevant articles and documents
Preparation method of 2-chlorine-4-fluorine-benzaldehyde
-
Paragraph 0037-0063, (2020/12/30)
The invention relates to a preparation method of 2-chlorine-4-fluorine benzaldehyde, and the method comprises the following steps: under stirring, adding 4-fluorine benzaldehyde into an acid solution,heating to 40-80 DEG C, and adding a chloramine chlorination reagent for reaction, cooling to room temperature, and carrying out after-treatment on the reaction solution to obtain the 2-chlorine-4-fluorine benzaldehyde, wherein the chloramine chlorination reagent is added in three batches: the first batch of chloramine chlorination reagent is added for reaction for 4 hours, then the second batchof chloramine chlorination reagent is added for reaction for 4 hours, finally the third batch of chloramine chlorination reagent is added to continuously react for 12 to 24 hours until the reaction iscompleted. According to the method disclosed by the invention, the yield of the product is 85wt%-94wt%. The raw materials involved in the method are commercialized reagents which are cheap and easy to obtain, the chloramine chlorination reagent is an environment-friendly reagent, the reaction only needs one step, and the product is simple and convenient to purify; and the method provided by the invention has good industrial potential and application value.
TEMPO-mediated oxidation of primary alcohols to aldehydes under visible light and air
Liu, Dongwang,Zhou, Hongxia,Gu, Xiangyong,Shen, Xiaoqin,Li, Pixu
supporting information, p. 117 - 122 (2014/03/21)
A homogeneous visible light photoredox TEMPO-mediated selective oxidation of primary alcohols to the corresponding carbonyl compounds was developed using molecular oxygen from air as the terminal oxidant. Ru(bpy)3(PF 6)2 (bpy: bipyridyl) and Ir(dtb-bpy)(ppy) 2(PF6) (dtb-bpy: 4,4′-di-tert-butyl-2,2′- bipyridyl; ppy: 2-phenylpyridine) were used as the sensitizers. A homogeneous visible light photoredox TEMPO-mediated selective oxidation of primary alcohols to the corresponding carbonyl compounds was developed. Molecular oxygen from air was the terminal oxidant. Copyright
'HALEX' FLUORINATION OF CHLORINATED BENZALDEHYDES AND BENZOYL CHLORIDES
Banks, R. Eric,Mothersdale, Kevin N.,Tipping, Anthony E.,Tsiliopoulos, Efthimios,Cozens, Barry J.,et al.
, p. 529 - 537 (2007/10/02)
Spray-dried potassium fluoride, suspended in sulpholane at 220 degC, converted 2,4- and 2,6-dichlorobenzaldehyde into the corresponding difluoroaldehydes (yields ca. 65percent).Small amounts of the mono-substituted products (2-chloro-4-fluoro- + 4-chloro-2-fluorobenzaldehyde, and 2-chloro-6-fluoro-benzaldehyde, respectively) were also produced.Similar treatment of the 3,4-dichloro-analogue gave 3-chloro-4-fluorobenzaldehyde (yield 98percent, conversion 68percent), but 2- and 4-chlorobenzaldehyde gave very poor yields (ca. 5percent) of the 2- and 4-fluoro-derivatives. 2-Fluoro-, 4-fluoro- and 3-chloro-4-fluorobenzoyl fluoride were obtained (yields 60-65percent) by heating the corresponding chlorobenzoyl chlorides with potassium fluoride in sulpholane.