842169-79-3

Basic information

• Product Name: Silanamine, N-[1-(4-bromophenyl)-2,2,2-trifluoroethylidene]-1,1,1-trimethyl-
• CAS NO: 842169-79-3
• Molecular Formula: C11H13BrF3NSi
• Molecular Weight: 324.216
• Mol File: 842169-79-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Silanamine, N-[1-(4-bromophenyl)-2,2,2-trifluoroethylidene]-1,1,1-trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silanamine, N-[1-(4-bromophenyl)-2,2,2-trifluoroethylidene]-1,1,1-trimethyl-(842169-79-3)
• EPA Substance Registry System: Silanamine, N-[1-(4-bromophenyl)-2,2,2-trifluoroethylidene]-1,1,1-trimethyl-(842169-79-3)

Safety Data

• Hazardous Substances Data: 842169-79-3(Hazardous Substances Data)

Upstream product

• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 
• 4039-32-1 lithium hexamethyldisilazane 

Downstream Products

• 778565-93-8 (R)-1-(4-bromophenyl)-2,2,2-trifluoroethanamine 
• 336105-43-2 (1S)-1-(4-bromophenyl)-2,2,2-trifluoroethanamine hydrochloride 
• 842169-80-6 1-(2,2,2-trifluoro)-1-(4-bromophenyl)ethylimine 

Relevant articles and documents

Access to Unprotected β-Fluoroalkyl β-Amino Acids and Their α-Hydroxy Derivatives

Unprotected β-(het)aryl-β-fluoroalkyl β-amino acids and their α-hydroxy derivatives can be readily obtained using a decarboxylative Mannich-type reaction without protection/deprotection steps. This protocol utilizes lithium hexamethyldisilazide and (het)arylfluoroalkyl ketones to generate NH-ketimine intermediates. The mild reaction conditions allow the preparation of original fluorinated β-amino acids as useful building blocks in a practical and scalable manner.