84277-81-6

Basic information

• Product Name: L-2-Aminodecanoic acid(S-form)
• Synonyms: L-2-Aminodecanoic acid(S-form);S-form;L-decyline;Nsc206258;L-decyline L-2-AMinodecanoic acid(S-forM);(2S)-2-AMino-decanoic acid;(S)-2-Aminodecanoic acid
• CAS NO: 84277-81-6
• Molecular Formula: C₁₀H₂₁NO₂
• Molecular Weight: 187.281
• Mol File: 84277-81-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 300.9±25.0 °C(Predicted)
• Appearance: /
• Density: 0.973
• PKA: 2.55±0.24(Predicted)
• CAS DataBase Reference: L-2-Aminodecanoic acid(S-form)(CAS DataBase Reference)
• NIST Chemistry Reference: L-2-Aminodecanoic acid(S-form)(84277-81-6)
• EPA Substance Registry System: L-2-Aminodecanoic acid(S-form)(84277-81-6)

Safety Data

• Hazardous Substances Data: 84277-81-6(Hazardous Substances Data)

Usage

General Description

L-2-Aminodecanoic acid (S-form) is a compound with the chemical formula C10H21NO2. It is an amino acid derivative, with a molecular weight of 187.28 g/mol. This chemical is a white crystalline solid that is soluble in water and ethanol. It is utilized in various industries, including pharmaceuticals, cosmetics, and food additives. It is also used in biochemical research and as a building block for the synthesis of other compounds. L-2-Aminodecanoic acid (S-form) has potential applications in drug development and can be used as a precursor in the manufacturing of specific pharmaceuticals and bioactive compounds.

Upstream product

• 333-60-8 2-oxodecanoic acid 
• 3060-50-2 2,2-diphenylglycine 

Downstream Products

• 70267-29-7 (S)-2-Hydroxydecanoic acid 
• 70267-24-2 (R)-2-hydroxydecanoic acid 
• 117560-23-3 benzyl (2S)-2-aminodecanoate 
• 89371-45-9 (S)-2-((S)-1-Carboxy-ethylamino)-decanoic acid benzyl ester 
• 89371-52-8 (4S)-1-benzyl-3-<(2S)-2-amino>propionyl>-2-oxoimidazolidine-4-carboxylic acid 
• 89371-49-3 (S)-1-Benzyl-3-[(S)-2-((S)-1-ethoxycarbonyl-nonylamino)-propionyl]-2-oxo-imidazolidine-4-carboxylic acid 
• 89371-40-4 benzyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate 
• 89371-73-3 tert.-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]-n-butyryl}-2-oxo-imidazolidine-4-carboxylate 
• 89384-27-0 benzyl (4S)-1-benzyl-3-{(2S)-[N-((1S)-1-ethoxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate 
• 89384-28-1 benzyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate 
• 117560-13-1 (S)-2-((S)-1-Benzyloxycarbonyl-ethylamino)-decanoic acid ethyl ester; compound with (Z)-but-2-enedioic acid 
• 117560-12-0 (S)-2-((S)-1-tert-Butoxycarbonyl-ethylamino)-decanoic acid benzyl ester; compound with (Z)-but-2-enedioic acid 
• 89371-90-4 (S)-2-((S)-1-Benzyloxycarbonyl-ethylamino)-decanoic acid ethyl ester 
• 117560-11-9 (S)-2-((S)-1-tert-Butoxycarbonyl-ethylamino)-decanoic acid benzyl ester 

Relevant articles and documents

Asymmetric synthesis of (S)-α-(octyl)glycine via alkylation of Ni(II) complex of chiral glycine Schiff base

Over last decade, the use of Ni(II) complexes, derived from of glycine Schiff bases with chiral tridentate ligands, has emerge as a leading methodology for preparation of structurally diverse Tailor-Made Amino Acids, the key structural units in modern medicinal chemistry, and drug design. Here, we report asymmetric synthesis of derivatives of (S)-α-(octyl)glycine ((S)-2-aminodecanoic acid) and its N-Fmoc derivative via alkylation of chiral nucleophilic glycine equivalent with n-octyl bromide. Under the optimized conditions, the alkylation proceeds with excellent yield (98.1%) and diastereoselectivity (98.8% de). The observed stereochemical outcome and convenient reaction conditions bode well for application of this method for large-scale asymmetric synthesis of (S)-2-aminodecanoic acid and its derivatives.