84547-61-5

Basic information

• Product Name: 5-(Hydroxymethyl)-1-methyl-1H-pyrazole
• Synonyms: (1-Methyl-1H-pyrazol-5-yl)methanol;5-(Hydroxymethyl)-1-methyl-1H-pyrazole;1H-pyrazole-5-methanol, 1-methyl-;(2-methyl-3-pyrazolyl)methanol;(2-methylpyrazol-3-yl)methanol;1-Methylpyrazole-5-methanol
• CAS NO: 84547-61-5
• Molecular Formula: C₅H₈N₂O
• Molecular Weight: 112.12982
• Mol File: 84547-61-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 55-59.5
• Boiling Point: 243.6 °C at 760 mmHg
• Flash Point: 101.1 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 0.0171mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: 2-8°C
• PKA: 14.35±0.10(Predicted)
• CAS DataBase Reference: 5-(Hydroxymethyl)-1-methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Hydroxymethyl)-1-methyl-1H-pyrazole(84547-61-5)
• EPA Substance Registry System: 5-(Hydroxymethyl)-1-methyl-1H-pyrazole(84547-61-5)

Safety Data

• Hazardous Substances Data: 84547-61-5(Hazardous Substances Data)

Usage

General Description

5-(Hydroxymethyl)-1-methyl-1H-pyrazole is a chemical compound with the molecular formula C5H8N2O. It is a white crystalline solid with a molecular weight of 112.13 g/mol. 5-(Hydroxymethyl)-1-methyl-1H-pyrazole is commonly used as a reagent in chemical reactions, particularly in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in the production of polymers and other organic compounds. 5-(Hydroxymethyl)-1-methyl-1H-pyrazole is considered to be of low toxicity, with no significant hazards associated with its handling and use. Overall, this chemical compound has various applications in the fields of chemistry, pharmaceuticals, and materials science.

InChI:InChI=1/C5H8N2O/c1-7-5(4-8)2-3-6-7/h2-3,8H,4H2,1H3

Upstream product

• 84547-59-1 2-methyl-2H-pyrazole-3-carbonyl chloride 
• 27258-33-9 1-methyl-1H-pyrazole-5-carbaldehyde 
• 17827-60-0 methyl 1-methyl-1H-pyrazole-5-carboxylate 
• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 
• 930-36-9 1-methyl-1H-pyrazole 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1071814-23-7 2-(4-bromo-1-methyl-1H-pyrazol-5-yl)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}acetamide 
• 1071814-24-8 N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-2-(4-fluoro-1-methyl-1H-pyrazol-5-yl)acetamide 
• 1071814-22-6 2-(4-chloro-1-methyl-1H-pyrazol-5-yl)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}acetamide 
• 1071814-21-5 N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-2-(1-methyl-1H-pyrazol-5-yl)acetamide 
• 1071814-44-2 2-(1-methyl-1H-pyrazol-5-yl)acetic acid 
• 1607023-51-7 5-(3,4-dichlorophenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1607023-29-9 5-(4-fluoro-3-methoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1607023-28-8 5-(3-ethoxy-4-fluorophenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1607023-26-6 5-(4-chloro-3-isopropoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1071814-43-1 2-(1-methyl-1H-pyrazol-5-yl)acetonitrile 
• 1607023-01-7 5-(4-chloro-3-methoxyphenyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 84547-63-7 5-(chloromethyl)-1-methyl-1H-pyrazole 
• 84547-71-7 1-methyl-5-(p-nitrostyryl)pyrazole 
• 132668-86-1 trans, trans-1,4-bis<2-(1-methylpyrazol-5-yl)vinyl>benzene 

Relevant articles and documents

Addressing the Metabolic Stability of Antituberculars through Machine Learning

We present the first prospective application of our mouse liver microsomal (MLM) stability Bayesian model. CD117, an antitubercular thienopyrimidine tool compound that suffers from metabolic instability (MLM t1/2 1/2 values greater than or equal to 60 min. It is noteworthy that whole-cell efficacy and lack of relative mammalian cell cytotoxicity could not be predicted simultaneously. These results support the utility of our new MLM stability model in chemical tool and drug discovery optimization efforts.

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

PYRAZOLE DERIVATIVES AS P2X7 MODULATORS

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein R1 represents C1-6 alkyl or C3-6 cycloalkyl, either of which is optionally substituted with 1, 2 or 3 ha