84565-04-8

Basic information

• Product Name: (Z)-6-Phenyl-hex-4-enoic acid
• Synonyms: (Z)-6-Phenyl-hex-4-enoic acid
• CAS NO: 84565-04-8
• Molecular Weight: 190.242
• Mol File: 84565-04-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (Z)-6-Phenyl-hex-4-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-6-Phenyl-hex-4-enoic acid(84565-04-8)
• EPA Substance Registry System: (Z)-6-Phenyl-hex-4-enoic acid(84565-04-8)

Safety Data

• Hazardous Substances Data: 84565-04-8(Hazardous Substances Data)

Upstream product

• 21963-38-2 5-vinyl-dihydrofuran-2(3H)-one 
• 300-57-2 allylbenzene 
• 87256-39-1 2,3,4,7-tetrahydrooxepin-2-one 
• 591-51-5 phenyllithium 
• 100-58-3 phenylmagnesium bromide 
• 424835-03-0 2-ethoxy-5-vinyltetrahydrofurane 

Relevant articles and documents

Unravelling the olefin cross metathesis on solid support. Factors affecting the reaction outcome

Olefin cross metathesis on solid support under a variety of conditions is described. A comprehensive analysis considering diverse factors governing the reaction outcome gives a series of patterns for the application of this useful methodology in organic synthesis. If the intrasite reaction is not possible, homodimerization of the soluble olefin is crucial. When the homodimer is less reactive than its monomer, reaction outcome depends on the homodimerization rate, which, in turn, depends on the precatalyst used and the reaction conditions. If the site-site interaction is a feasible process, the cross metathesis product is obtained exclusively when the newly-formed double bond is resilient to further metathetic events. Taking into account these considerations, we have demonstrated that excellent results in terms of cross metathesis coupling can be obtained under the optimized conditions, and that microwave irradiation is also an interesting alternative for the development of a practical and energy-efficient cross metathesis on solid support.

SIMPLE METHODS FOR, THE SYNTHESIS OF (E)-4- AND (E)-5-ALKENOIC ACIDS BY THE SN2' TYPE REACTIONS OF γ-VINYL-γ-BUTYROLACTONE AND δ-VINYL-δ-VALEROLACTONE WITH ORGANOCOPPER REAGENTS

γ-Vinyl-γ-butyrolactone and δ-vinyl-δ-valerolactone react regio- and stereoselectively with Grignard reagents in the presence of a copper(I) catalyst or with diorganocuprates to afford (E)-4- and (E)-5-alkenoic acids, respectively, in high yields.Synthetic utility of the former reaction is demonstrated in the simple synthesis of (4E,7Z)-4,7-tridecadienyl acetate.