85475-01-0 Usage
Description
Hydroxy-PEG1-methylamine is a PEG (polyethylene glycol) linker that features a hydroxyl group attached to a methylamine group. This molecule is designed to enhance solubility in aqueous environments due to the hydrophilic nature of the PEG spacer. The presence of the hydroxyl group allows for additional chemical modifications or the attachment of other reactive functional groups. Furthermore, the methylamine group is capable of reacting with carboxylic acids, carbonyls (including ketones and aldehydes), making Hydroxy-PEG1-methylamine a versatile building block in various chemical and pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
Hydroxy-PEG1-methylamine serves as a key component in the development of drug conjugates and prodrugs. Its reactivity with carboxylic acids and carbonyls facilitates the formation of stable covalent bonds with drug molecules, enhancing their solubility, stability, and bioavailability in the body.
Used in Bioconjugation:
In the field of bioconjugation, Hydroxy-PEG1-methylamine is utilized as a linking agent to attach biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The hydroxyl group allows for further derivatization, enabling the attachment of various functional groups to tailor the properties of the final conjugate.
Used in Drug Delivery Systems:
Hydroxy-PEG1-methylamine is employed in the design of drug delivery systems to improve the therapeutic efficacy and reduce side effects of drugs. The PEG linker can be used to create long-circulating nanoparticles or micelles, which can encapsulate drugs and control their release rate, leading to better pharmacokinetics and biodistribution.
Used in Chemical Synthesis:
In chemical synthesis, Hydroxy-PEG1-methylamine acts as an intermediate or a building block for the synthesis of more complex molecules. Its reactive groups can be used to create a variety of PEGylated compounds with tailored properties for specific applications, such as enhanced solubility, stability, or targeting capabilities.
Used in Surface Modification:
Hydroxy-PEG1-methylamine is used for modifying surfaces of materials, such as nanoparticles, polymers, or solid supports, to impart specific properties like hydrophilicity, biocompatibility, or resistance to protein adsorption. The PEG linker can provide a stable and flexible coating that can be further functionalized as needed.
Check Digit Verification of cas no
The CAS Registry Mumber 85475-01-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,4,7 and 5 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 85475-01:
(7*8)+(6*5)+(5*4)+(4*7)+(3*5)+(2*0)+(1*1)=150
150 % 10 = 0
So 85475-01-0 is a valid CAS Registry Number.
85475-01-0Relevant articles and documents
Enhanced product selectivity in continuous N-methylation of amino alcohols over solid acid-base catalysts with supercritical methanol
Oku, Tomoharu,Ikariya, Takao
, p. 3476 - 3479 (2007/10/03)
The unique properties of supercritical fluids can be exploited for fine-tuning product selectivity. Under the conditions listed for the N-methylation of amino alcohols (see scheme) over solid acid-base bifunctional catalysts, the total yield and product selectivity could be improved. Enhanced product selectivity might be attributed to the milder reaction conditions possible with supercritical methanol, as well as the increased concentration of methanol on the catalyst.
