85653-34-5Relevant articles and documents
Antimicrobial activity of quasi-enantiomeric cinchona alkaloid derivatives and prediction model developed by machine learning
Ga?parovic, Ana Cipak,Hrenar, Tomica,Mikelic, Ana,Milkovic, Lidija,Od?ak, Renata,Primo?ic, Ines,Ramic, Alma,Skocibu?ic, Mirjana,Sovic, Karlo
, (2021/06/16)
Bacterial infections that do not respond to current treatments are increasing, thus there is a need for the development of new antibiotics. Series of 20 N-substituted quaternary salts of cinchonidine (CD) and their quasi-enantiomer cinchonine (CN) were pr
Ring-Strain-Enabled Catalytic Asymmetric Umpolung C-O Bond-Forming Reactions of 1,2-Oxazetidines for the Synthesis of Functionalized Chiral Ethers
Wu, Binyu,Yang, Jinggang,Gao, Min,Hu, Lin
supporting information, p. 5561 - 5566 (2020/07/14)
An unprecedented catalytic asymmetric umpolung C-O bond-forming reaction of N-nosyl 1,2-oxazetidines with β-keto esters has been achieved in the presence of a chiral phase-transfer catalyst, allowing access to a range of highly functionalized chiral ethers bearing quaternary and no adjacent stereogenic centers with high yields, excellent enantioselectivities, and diastereoselectivities (up to 97percent ee and 20:1 dr). These versatile products could be flexibly transformed into biologically important chiral fused and spiro morpholines in two steps.
ENANTIOENRICHED VIRIDICATUMTOXIN B ANALOGS
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Page/Page column 65; 66, (2017/11/10)
In one aspect, the present disclosure provides derivatives of viridicatumtoxin of the formula wherein the variables are as defined herein. Also provided herein are compositions and methods of treating a bacterial infection, a viral infection, or in the treatment of cancer. The present disclosure also provides methods of synthesizing enantiopure viridicatumtoxin and other anthrone compounds.