86-12-4 Usage
Description
Thenalidine, also known as Sanbosten, is an antihistamine with anticholinergic properties. It is a pharmaceutical compound that exhibits a range of therapeutic effects, making it a versatile drug for various medical applications.
Uses
Used in Pharmaceutical Industry:
Thenalidine is used as an antipruritic drug for the treatment of itching and other allergic symptoms. Its antihistamine properties help to alleviate the discomfort associated with histamine release during allergic reactions.
Additionally, due to its anticholinergic properties, thenalidine may also be used in the management of certain conditions that involve excessive cholinergic activity, such as gastrointestinal disorders or urinary incontinence. However, it is important to note that the use of thenalidine in these applications may be limited due to its potential side effects and the availability of other more targeted treatments.
World Health Organization (WHO)
Thenalidine, a piperidine antihistamine, was introduced in 1953
for the management of dermatologic and allergic conditions. By 1958 its use had
been associated with cases of severe neutropenia, two of them fatal, which led to
its withdrawal in the United States of America and subsequently in the United
Kingdom. Over the next fifteen years, continued reports of its association with
cases of neutropenia resulted in further withdrawals in many countries. It is
apparently still available, however, in some combination products.
Check Digit Verification of cas no
The CAS Registry Mumber 86-12-4 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 86-12:
(4*8)+(3*6)+(2*1)+(1*2)=54
54 % 10 = 4
So 86-12-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H22N2S/c1-18-11-9-16(10-12-18)19(14-17-8-5-13-20-17)15-6-3-2-4-7-15/h2-8,13,16H,9-12,14H2,1H3