86060-81-3 Usage
Description
Fmoc-S-acetamidomethyl-L-cysteine, also known as Fmoc-cys(acm)-oh, is an amino acid building block that plays a crucial role in peptide synthesis. It is a derivative of the naturally occurring amino acid L-cysteine, with an Fmoc (9-fluorenylmethoxycarbonyl) protecting group and an acetamidomethyl (AcM) moiety attached to the sulfur atom. This modification enhances the stability and solubility of the molecule, making it an ideal component for the synthesis of various peptides and proteins.
Uses
Used in Pharmaceutical Industry:
Fmoc-S-acetamidomethyl-L-cysteine is used as a key building block for the synthesis of therapeutic peptides and proteins. Its unique structure allows for the incorporation of L-cysteine residues into peptide sequences with improved stability and solubility, which is essential for the development of effective peptide-based drugs.
Used in Research and Development:
In the field of research and development, Fmoc-S-acetamidomethyl-L-cysteine serves as an important tool for the synthesis of novel peptide sequences with potential biological activities. Its use in the development of new therapeutic agents and the study of peptide-protein interactions contributes to the advancement of biomedical sciences.
Used in Peptide Drug Market:
With the growing peptide drug market, the fast and reliable synthesis of peptides is of great importance. Fmoc-S-acetamidomethyl-L-cysteine plays a vital role in this process, as it enables the efficient and accurate assembly of peptide sequences, leading to the production of high-quality peptide-based drugs.
Used in Peptide Synthesis Education:
Fmoc-S-acetamidomethyl-L-cysteine is also utilized in educational settings, where it serves as a valuable teaching tool for students learning about peptide synthesis and the role of amino acid building blocks in the development of pharmaceuticals and other biotechnological applications.
Check Digit Verification of cas no
The CAS Registry Mumber 86060-81-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,0,6 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 86060-81:
(7*8)+(6*6)+(5*0)+(4*6)+(3*0)+(2*8)+(1*1)=133
133 % 10 = 3
So 86060-81-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H22N2O5S/c1-13(24)22-12-29-11-19(20(25)26)23-21(27)28-10-18-16-8-4-2-6-14(16)15-7-3-5-9-17(15)18/h2-9,18-19H,10-12H2,1H3,(H,22,24)(H,23,27)(H,25,26)/t19-/m1/s1
86060-81-3Relevant articles and documents
MgI2-chemoselective cleavage for removal of amino acid protecting groups: A fresh vision for peptide synthesis
Berthet, Mathéo,Martinez, Jean,Parrot, Isabelle
, (2017/03/30)
In the field of peptide synthesis, the key to a successful access to synthetic targets lies on a pertinent combination of protecting groups. Their choice is directed by their selective removal conditions. We present here the behavior of some of the most used protecting groups in peptide chemistry under experimental cleavage conditions, combining MgI2 with MW irradiation, using 2-Me-THF as a green solvent. In these experimental conditions, the benzyloxycarbonyl protecting group as well as the Merrifield resin can be re-considered in peptide chemistry.
Treatment of obesity
-
, (2008/06/13)
A method for the treatment of obesity in an animal such as a human, comprises administering to the animal an effective amount of a peptide which comprises an analogue of the carboxyl-terminal sequence of a growth hormone, particularly an analogue of the carboxyl-terminal sequence of human growth hormone containing amino acid residues 177-191. A pharmaceutical composition for use in the treatment of obesity is also disclosed.
One-Pot Synthesis of S-Acetamidomethyl-N-fluorenylmethoxycarbonyl-L-cysteine (Fmoc-Cys(Acm)-OH)
Albericio, F.,Grandas, A.,Porta, A.,Pedroso, E.,Giralt, E.
, p. 271 - 272 (2007/10/02)
A new strategy for the preparation of S-acetamidomethyl-N-fluorenylmethoxycarbonyl-L-cysteine is reported.Inexpensive, readily available reagents are used, and no special equipment is required.A very homogenous product is obtained after a simple crystallization at the end of the process, without purification of intermediates.
