861430-44-6

Basic information

• Product Name: 2,3-bis(nitrooxy)propyl (2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-[4-(methylsulfonyl)phenyl]-3-phenylbut-2-en-1-yl carbonate
• Synonyms: 2,3-bis(nitrooxy)propyl (2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-[4-(methylsulfonyl)phenyl]-3-phenylbut-2-en-1-yl carbonate
• CAS NO: 861430-44-6
• Molecular Weight: 640.741
• Mol File: 861430-44-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,3-bis(nitrooxy)propyl (2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-[4-(methylsulfonyl)phenyl]-3-phenylbut-2-en-1-yl carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-bis(nitrooxy)propyl (2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-[4-(methylsulfonyl)phenyl]-3-phenylbut-2-en-1-yl carbonate(861430-44-6)
• EPA Substance Registry System: 2,3-bis(nitrooxy)propyl (2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-[4-(methylsulfonyl)phenyl]-3-phenylbut-2-en-1-yl carbonate(861430-44-6)

Safety Data

• Hazardous Substances Data: 861430-44-6(Hazardous Substances Data)

Upstream product

• 654068-92-5 (2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-[4-(methylsulfonyl)phenyl]-3-phenylbut-2-en-1-ol 
• 621-65-8 glyceryl 1,2-dinitrate 

Downstream Products

• 861430-45-7 2,3-bis(nitrooxy)propyl (2Z)-4-hydroxy-2-[4-(methylsulfonyl)phenyl]-3-phenylbut-2-en-1-yl carbonate 

Relevant articles and documents

NITRIC OXIDE RELEASING PRODRUGS OF DIARYL-2-(5H)-FURANONES AS CYCLOOXYGENASE-2 INHIBITORS

The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases. Formula (I). The invention also encompasses certain pharmaceutical compositions and methods for treating cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula 1. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while also reducing the risk of thrombotic cardiovascular events.