869-24-9 Usage
Description
2-Diethylaminoethylchloride hydrochloride, also known as 2-Chloro-N,N-diethylethylamine hydrochloride, is a colorless to beige crystalline compound that serves as a versatile intermediate in the synthesis of various pharmaceuticals and chemical compounds.
Uses
Used in Pharmaceutical Industry:
2-Diethylaminoethylchloride hydrochloride is used as an intermediate for the syntheses of pharmaceuticals such as amiodarone, butetamate citrate, flurazepam, and naftidrofuryl. It plays a crucial role in the production of these medications, contributing to their therapeutic effects.
Used in Organic Chemistry:
2-Diethylaminoethylchloride hydrochloride can be used as an alkylating reagent for the synthesis of various chemical compounds, including:
Substituted oxindole derivatives, which are used as growth hormone secretagogues.
1-Substituted-5,6-dinitrobenzimidazoles, which possess antimicrobial and antiprotozoal activities.
Thiophene-containing triarylmethane (TRAM) derivatives, which are used as antitubercular agents.
Used in Polymer Chemistry:
2-Diethylaminoethylchloride hydrochloride is used in combination with CuBr as a catalyst (Et6TREN/CuBr) for atom transfer radical polymerization of n-butyl acrylate, a process that enables the synthesis of polymers with controlled molecular weight and architecture.
Used in Chitosan Modification:
It can also be used for the derivatization of chitosan to incorporate amino functionality onto its C-6 position, enhancing the properties and applications of chitosan in various fields, such as drug delivery, tissue engineering, and water treatment.
Purification Methods
Crystallise the salt from absolute MeOH (to remove highly coloured impurities). [Beilstein 4 III 240.]
Check Digit Verification of cas no
The CAS Registry Mumber 869-24-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,6 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 869-24:
(5*8)+(4*6)+(3*9)+(2*2)+(1*4)=99
99 % 10 = 9
So 869-24-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H14ClN/c1-3-8(4-2)6-5-7/h3-6H2,1-2H3/p+1
869-24-9Relevant articles and documents
Preparation method for high-yield N, N-diethylethylenediamine
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Paragraph 0019, (2018/12/14)
The invention discloses a preparation method for high-yield N, N-diethylethylenediamine. The method comprises the following steps that 2-diethylaminoethylchloride hydrochloride and benzyl carbamate are added into a sodium hydroxide solution, a palladium-carbon catalyst is added, heating is carried out so as to reach 55-65 DEG C for reaction for 4-7 hours under a sealed condition, alkali is added into reaction liquid for cooling and alkali precipitation, lower-layer alkali liquor and the palladium-carbon catalyst are separated, an organic layer is subjected to rectification treatment, and a fraction of 142-148 DEG C is collected so as to obtain the N,N-diethylethylenediamine. The method has the advantages that the reaction conditions are mild, no harmful gas is adopted or generated in the reaction process, and meanwhile, the yield of the N,N-diethylethylenediamine is high.
Coumadin female phenol split-ring analogue and its medical use
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Paragraph 0045-0047, (2017/10/06)
The invention relates to the field of pharmaceutical chemistry, in particular to a coumestrol open-ring analogue with structures as shown in general formulae I and II and a medical application thereof, especially an application to the preparation of drugs as angiogenesis inhibition and vascular disruption agents.
INDENOISOQUINOLINONE DERIVATIVES, MANUFACTURING METHOD AND MEDICAL USE THEREOF
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Paragraph 0060; 0061, (2013/04/13)
Indenoisoquinolinone derivatives (I), the manufacturing method and the medical use thereof, which belong to pharmaceutical chemistry and organic chemistry field, are disclosed. These compounds can be used for treating several medical symptoms related to postmenopausal syndrome, uterine fibers deterioration and aortic smooth muscle cells proliferation, especially ER-(+) depend breast cancer. Meanwhile, these compounds can also be used for treating glioma and lung cancer, and have inhibiting effect on tumor metastasis effect on tumor metastasis.