869901-69-9

Basic information

• Product Name: MK-2048
• Synonyms: Pyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, 2-[(3-chloro-4-fluorophenyl)methyl]-8-ethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-N,6-dimethyl-1,9-dioxo-, (6S)-;(S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-diMethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxaMide;(6S)-2-[(3-Chloro-4-fluorophenyl)methyl]-8-ethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-N,6-dimethyl-1,9-dioxopyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide
• CAS NO: 869901-69-9
• Molecular Formula: C22H24FN5O4
• Molecular Weight: 441.4554632
• Product Categories: Inhibitors
• Mol File: 869901-69-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.55
• CAS DataBase Reference: MK-2048(CAS DataBase Reference)
• NIST Chemistry Reference: MK-2048(869901-69-9)
• EPA Substance Registry System: MK-2048(869901-69-9)

Safety Data

• Hazardous Substances Data: 869901-69-9(Hazardous Substances Data)

Usage

Description

MK-2048 is a prototype second-generation integrase strand transfer inhibitor (INSTI) that was developed to maintain activity against HIV viruses with mutations associated with resistance to first-generation INSTIs, such as raltegravir (R100312). It demonstrates potent inhibitory activity against HIV integrase and HIV replication, being four times more effective in inhibiting the HIV enzyme integrase than the first-generation inhibitor, raltegravir.

Uses

Used in Pharmaceutical Industry:
MK-2048 is used as an antiviral agent for the treatment of HIV infections. It is effective against HIV strains that have developed resistance to first-generation INSTIs, making it a valuable option for patients who have not responded well to earlier treatments.
MK-2048 is used as a research tool for studying the mechanisms of HIV integrase and the development of resistance to INSTIs. This helps in understanding the virus's behavior and contributes to the development of more effective antiretroviral therapies.
MK-2048 is also used in the development of new drug formulations and delivery systems to improve the bioavailability, efficacy, and safety of HIV treatments, potentially leading to better patient outcomes and adherence to therapy.

Upstream product

• 192702-01-5 3-chloro-4-fluorobenzyl bromide 

Relevant articles and documents

HIV INTEGRASE INHIBITORS

Hydroxy-substituted pyrazinopyrrolopyridazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.