87432-82-4Relevant articles and documents
Direct, Regiospecific 2-Lithiation of Pyridines and Pyridine 1-Oxides with in Situ Electrophilic Trapping
Taylor, Stephen L.,Lee, David Y.,Martin, J. C.
, p. 4156 - 4158 (1983)
Efficient synthetic routes to 2-substituted pyridines and 2,6-disubstituted pyridine 1-oxides involving direct lithiation with the sterically hindered base lithium 2,2,6,6-tetramethylpiperidide (LiTMP) in the presence of electrophiles that are compatible with the base, e.g., trimethylsilyl chloride (Me3SiCl) and hexafluoroacetone (HFA), are described.